Improving laboratory animal genetic reporting: LAG-R guidelines

Lydia Teboul (), James Amos-Landgraf, Fernando J. Benavides, Marie-Christine Birling, Steve D. M. Brown, Elizabeth Bryda, Rosie Bunton-Stasyshyn, Hsian-Jean Chin, Martina Crispo, Fabien Delerue, Michael Dobbie, Craig L. Franklin, Ernst-Martin Fuchtbauer, Xiang Gao, Christelle Golzio, Rebecca Haffner, Yann Hérault, Martin Hrabe de Angelis, Kevin C. Kent Lloyd, Terry R. Magnuson, Lluis Montoliu, Stephen A. Murray, Ki-Hoan Nam, Lauryl M. J. Nutter, Eric Pailhoux, Fernando Pardo Manuel de Villena, Kevin Peterson, Laura Reinholdt, Radislav Sedlacek, Je Kyung Seong, Toshihiko Shiroishi, Cynthia Smith, Toru Takeo, Louise Tinsley, Jean-Luc Vilotte, Søren Warming, Sara Wells, C. Bruce Whitelaw, Atsushi Yoshiki and Guillaume Pavlovic ()
Additional contact information
Lydia Teboul: Harwell Campus
James Amos-Landgraf: University of Missouri School of Medicine
Fernando J. Benavides: The University of Texas MD Anderson Cancer Center
Marie-Christine Birling: Illkirch-Grafenstaden
Steve D. M. Brown: Illkirch-Grafenstaden
Elizabeth Bryda: University of Missouri
Rosie Bunton-Stasyshyn: Harwell Campus
Hsian-Jean Chin: NARLabs
Martina Crispo: Institut Pasteur de Montevideo, Mataojo 2020
Fabien Delerue: The University of Texas MD Anderson Cancer Center
Michael Dobbie: Australian National University
Craig L. Franklin: University of Missouri
Ernst-Martin Fuchtbauer: University of Aarhus
Xiang Gao: Nanjing University
Christelle Golzio: IGBMC UMR 7104- UMR-S 1258
Rebecca Haffner: Weizmann Institute of Science
Yann Hérault: Illkirch-Grafenstaden
Martin Hrabe de Angelis: Ingolstaedter Landstraße 1
Kevin C. Kent Lloyd: University of California Davis
Terry R. Magnuson: The University of North Carolina at Chapel Hill
Lluis Montoliu: National Centre for Biotechnology (CNB-CSIC)
Stephen A. Murray: The Jackson Laboratory
Ki-Hoan Nam: Korea Research Institute of Bioscience and Biotechnology (KRIBB)
Lauryl M. J. Nutter: The Hospital for Sick Children and The Centre for Phenogenomics
Eric Pailhoux: BREED
Fernando Pardo Manuel de Villena: University of North Carolina
Kevin Peterson: The Jackson Laboratory
Laura Reinholdt: The Jackson Laboratory
Radislav Sedlacek: Institute of Molecular Genetics of the Czech Academy of Sciences
Je Kyung Seong: Seoul National University, and Korea Mouse Phenotyping Center
Toshihiko Shiroishi: RIKEN BioResource Research Center (BRC)
Cynthia Smith: Jackson Laboratory
Toru Takeo: Kumamoto University
Louise Tinsley: Harwell Campus
Jean-Luc Vilotte: GABI
Søren Warming: a member of the Roche group
Sara Wells: Harwell Campus
C. Bruce Whitelaw: University of Edinburgh
Atsushi Yoshiki: RIKEN BioResource Research Center
Guillaume Pavlovic: Illkirch-Grafenstaden

Nature Communications, 2024, vol. 15, issue 1, 1-8

Abstract: Abstract The biomedical research community addresses reproducibility challenges in animal studies through standardized nomenclature, improved experimental design, transparent reporting, data sharing, and centralized repositories. The ARRIVE guidelines outline documentation standards for laboratory animals in experiments, but genetic information is often incomplete. To remedy this, we propose the Laboratory Animal Genetic Reporting (LAG-R) framework. LAG-R aims to document animals’ genetic makeup in scientific publications, providing essential details for replication and appropriate model use. While verifying complete genetic compositions may be impractical, better reporting and validation efforts enhance reliability of research. LAG-R standardization will bolster reproducibility, peer review, and overall scientific rigor.

Date: 2024
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DOI: 10.1038/s41467-024-49439-y

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