The dynamic world of the 8–17 DNAzyme

Jessica Felice Schmuck, Jan Borggräfe () and Manuel Etzkorn ()
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Jessica Felice Schmuck: Institute of Physical Biology
Jan Borggräfe: Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Neuherberg
Manuel Etzkorn: Institute of Physical Biology

Nature Communications, 2024, vol. 15, issue 1, 1-3

Abstract: DNA catalysts, known as DNAzymes, have arguably been limited for decades by the lack of mechanistic information. The solution structure of the 8–17 DNAzyme reported by Wieruszekska, Pwlowicz et al. reassesses the current thinking regarding the relationship between structure, dynamic, and metal ion coordination.

Date: 2024
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DOI: 10.1038/s41467-024-49500-w

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