Superporous sponge prepared by secondary network compaction with enhanced permeability and mechanical properties for non-compressible hemostasis in pigs

Tianshen Jiang, Sirong Chen, Jingwen Xu, Yuxiao Zhang, Hao Fu, Qiangjun Ling, Yan Xu, Xiangyu Chu, Ruinan Wang, Liangcong Hu, Hao Li, Weitong Huang, Liming Bian (), Pengchao Zhao () and Fuxin Wei ()
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Tianshen Jiang: South China University of Technology
Sirong Chen: South China University of Technology
Jingwen Xu: South China University of Technology
Yuxiao Zhang: South China University of Technology
Hao Fu: South China University of Technology
Qiangjun Ling: South China University of Technology
Yan Xu: The Seventh Affiliated Hospital of Sun Yat-sen University
Xiangyu Chu: Huazhong University of Science and Technology
Ruinan Wang: South China University of Technology
Liangcong Hu: Huazhong University of Science and Technology
Hao Li: First Affiliated Hospital of Sun Yat-sen University
Weitong Huang: South China University of Technology
Liming Bian: South China University of Technology
Pengchao Zhao: South China University of Technology
Fuxin Wei: The Seventh Affiliated Hospital of Sun Yat-sen University

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Developing superporous hemostatic sponges with simultaneously enhanced permeability and mechanical properties remains challenging but highly desirable to achieve rapid hemostasis for non-compressible hemorrhage. Typical approaches to improve the permeability of hemostatic sponges by increasing porosity sacrifice mechanical properties and yield limited pore interconnectivity, thereby undermining the hemostatic efficacy and subsequent tissue regeneration. Herein, we propose a temperature-assisted secondary network compaction strategy following the phase separation-induced primary compaction to fabricate the superporous chitosan sponge with highly-interconnected porous structure, enhanced blood absorption rate and capacity, and fatigue resistance. The superporous chitosan sponge exhibits rapid shape recovery after absorbing blood and maintains sufficient pressure on wounds to build a robust physical barrier to greatly improve hemostatic efficiency. Furthermore, the superporous chitosan sponge outperforms commercial gauze, gelatin sponges, and chitosan powder by enhancing hemostatic efficiency, cell infiltration, vascular regeneration, and in-situ tissue regeneration in non-compressible organ injury models, respectively. We believe the proposed secondary network compaction strategy provides a simple yet effective method to fabricate superporous hemostatic sponges for diverse clinical applications.

Date: 2024
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DOI: 10.1038/s41467-024-49578-2

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