Enhanced stress resilience in potato by deletion of Parakletos

Muhammad Awais Zahid, Nam Phuong Kieu, Frida Meijer Carlsen, Marit Lenman, Naga Charan Konakalla, Huanjie Yang, Sunmoon Jyakhwa, Jozef Mravec, Ramesh Vetukuri, Bent Larsen Petersen, Svante Resjö and Erik Andreasson ()
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Muhammad Awais Zahid: Swedish University of Agricultural Sciences
Nam Phuong Kieu: Swedish University of Agricultural Sciences
Frida Meijer Carlsen: University of Copenhagen
Marit Lenman: Swedish University of Agricultural Sciences
Naga Charan Konakalla: Swedish University of Agricultural Sciences
Huanjie Yang: Swedish University of Agricultural Sciences
Sunmoon Jyakhwa: Swedish University of Agricultural Sciences
Jozef Mravec: University of Copenhagen
Ramesh Vetukuri: Swedish University of Agricultural Sciences
Bent Larsen Petersen: University of Copenhagen
Svante Resjö: Swedish University of Agricultural Sciences
Erik Andreasson: Swedish University of Agricultural Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract Continued climate change impose multiple stressors on crops, including pathogens, salt, and drought, severely impacting agricultural productivity. Innovative solutions are necessary to develop resilient crops. Here, using quantitative potato proteomics, we identify Parakletos, a thylakoid protein that contributes to disease susceptibility. We show that knockout or silencing of Parakletos enhances resistance to oomycete, fungi, bacteria, salt, and drought, whereas its overexpression reduces resistance. In response to biotic stimuli, Parakletos-overexpressing plants exhibit reduced amplitude of reactive oxygen species and Ca2+ signalling, and silencing Parakletos does the opposite. Parakletos homologues have been identified in all major crops. Consecutive years of field trials demonstrate that Parakletos deletion enhances resistance to Phytophthora infestans and increases yield. These findings demark a susceptibility gene, which can be exploited to enhance crop resilience towards abiotic and biotic stresses in a low-input agriculture.

Date: 2024
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DOI: 10.1038/s41467-024-49584-4

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