Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios

Miranda L. Wilson, Shannon N. Romano, Nitya Khatri, Devora Aharon, Yulong Liu, Odelya H. Kaufman, Bruce W. Draper and Florence L. Marlow ()
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Miranda L. Wilson: and Regenerative Biology. Icahn School of Medicine at Mount Sinai. One Gustave L. Levy Place Box 1020
Shannon N. Romano: and Regenerative Biology. Icahn School of Medicine at Mount Sinai. One Gustave L. Levy Place Box 1020
Nitya Khatri: and Regenerative Biology. Icahn School of Medicine at Mount Sinai. One Gustave L. Levy Place Box 1020
Devora Aharon: and Regenerative Biology. Icahn School of Medicine at Mount Sinai. One Gustave L. Levy Place Box 1020
Yulong Liu: Department of Molecular and Cellular Biology. University of California. 1 Shields Ave
Odelya H. Kaufman: Department of Developmental and Molecular Biology. Albert Einstein College of Medicine
Bruce W. Draper: Department of Molecular and Cellular Biology. University of California. 1 Shields Ave
Florence L. Marlow: and Regenerative Biology. Icahn School of Medicine at Mount Sinai. One Gustave L. Levy Place Box 1020

Nature Communications, 2024, vol. 15, issue 1, 1-17

Abstract: Abstract Reproductive success relies on proper establishment and maintenance of biological sex. In many animals, including mammals, the primary gonad is initially ovary biased. We previously showed the RNA binding protein (RNAbp), Rbpms2, is required for ovary fate in zebrafish. Here, we identified Rbpms2 targets in oocytes (Rbpms2-bound oocyte RNAs; rboRNAs). We identify Rbpms2 as a translational regulator of rboRNAs, which include testis factors and ribosome biogenesis factors. Further, genetic analyses indicate that Rbpms2 promotes nucleolar amplification via the mTorc1 signaling pathway, specifically through the mTorc1-activating Gap activity towards Rags 2 (Gator2) component, Missing oocyte (Mios). Cumulatively, our findings indicate that early gonocytes are in a dual poised, bipotential state in which Rbpms2 acts as a binary fate-switch. Specifically, Rbpms2 represses testis factors and promotes oocyte factors to promote oocyte progression through an essential Gator2-mediated checkpoint, thereby integrating regulation of sexual differentiation factors and nutritional availability pathways in zebrafish oogenesis.

Date: 2024
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DOI: 10.1038/s41467-024-49613-2

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