Environmental and genetic regulation of Streptococcus pneumoniae galactose catabolic pathways

Banaz O. Kareem, Ozcan Gazioglu, Karina Mueller Brown, Medhanie Habtom, David G. Glanville, Marco R. Oggioni, Peter W. Andrew, Andrew T. Ulijasz, N. Luisa Hiller and Hasan Yesilkaya ()
Additional contact information
Banaz O. Kareem: University of Leicester
Ozcan Gazioglu: University of Leicester
Karina Mueller Brown: Carnegie Mellon University
Medhanie Habtom: University of Leicester
David G. Glanville: Loyola University Chicago
Marco R. Oggioni: University of Leicester
Peter W. Andrew: University of Leicester
Andrew T. Ulijasz: Loyola University Chicago
N. Luisa Hiller: Carnegie Mellon University
Hasan Yesilkaya: University of Leicester

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract Efficient utilization of nutrients is crucial for microbial survival and virulence. The same nutrient may be utilized by multiple catabolic pathways, indicating that the physical and chemical environments for induction as well as their functional roles may differ. Here, we study the tagatose and Leloir pathways for galactose catabolism of the human pathogen Streptococcus pneumoniae. We show that galactose utilization potentiates pneumococcal virulence, the induction of galactose catabolic pathways is influenced differentially by the concentration of galactose and temperature, and sialic acid downregulates galactose catabolism. Furthermore, the genetic regulation and in vivo induction of each pathway differ, and both galactose catabolic pathways can be turned off with a galactose analogue in a substrate-specific manner, indicating that galactose catabolic pathways can be potential drug targets.

Date: 2024
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DOI: 10.1038/s41467-024-49619-w

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