The maternal drug exposure birth cohort (DEBC) in China

Lu Li, Ke Wang, Meixian Wang, Jing Tao, Xiaohong Li, Zhen Liu, Nana Li, Xiaoxia Qiu, Hongwei Wei, Yuan Lin, Yuan He, Ying Deng, Hong Kang, Yuting Li, Ping Yu (), Yanping Wang (), Jun Zhu () and Hanmin Liu ()
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Lu Li: Sichuan University
Ke Wang: Sichuan University
Meixian Wang: Sichuan University
Jing Tao: Sichuan University
Xiaohong Li: Sichuan University
Zhen Liu: Sichuan University
Nana Li: Sichuan University
Xiaoxia Qiu: The Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region
Hongwei Wei: The Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region
Yuan Lin: Fuzhou
Yuan He: National Human Genetic Resource Center
Ying Deng: Sichuan University
Hong Kang: Sichuan University
Yuting Li: Sichuan University
Ping Yu: Sichuan University
Yanping Wang: Sichuan University
Jun Zhu: Sichuan University
Hanmin Liu: Ministry of Education

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Drug exposure during pregnancy lacks global fetal safety data. The maternal drug exposure birth cohort (DEBC) study, a prospective longitudinal investigation, aims to explore the correlation of maternal drug exposure during pregnancy with pregnancy outcomes, and establish a human biospecimen biobank. Here we describe the process of establishing DEBC and show that the drug exposure rate in the first trimester of pregnant women in DEBC (n = 112,986) is 30.70%. Among the drugs used, dydrogesterone and progesterone have the highest exposure rates, which are 11.97% and 10.82%, respectively. The overall incidence of adverse pregnancy outcomes is 13.49%. Dydrogesterone exposure during the first trimester is correlated with higher incidences of stillbirth, preterm birth, low birth weight, and birth defects, along with a lower incidence of miscarriage/abortion. Due to the limitations of this cohort study, causative conclusions cannot be drawn. Further follow-up and in-depth data analysis are planned for future studies.

Date: 2024
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DOI: 10.1038/s41467-024-49623-0

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