Systematic review and meta-analysis of birth outcomes in women with polycystic ovary syndrome

Mahnaz Bahri Khomami (), Somayeh Hashemi, Soulmaz Shorakae, Cheryce L. Harrison, Terhi T. Piltonen, Daniela Romualdi, Chau Thien Tay, Aya Mousa, Eszter Vanky and Helena J. Teede
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Mahnaz Bahri Khomami: Monash University
Somayeh Hashemi: Brock University
Soulmaz Shorakae: Monash University
Cheryce L. Harrison: Monash University
Terhi T. Piltonen: University of Oulu
Daniela Romualdi: Fondazione Policlinico Universitario A. Gemelli
Chau Thien Tay: Monash University
Aya Mousa: Monash University
Eszter Vanky: Norwegian University of Science and Technology
Helena J. Teede: Monash University

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract It is unclear whether polycystic ovary syndrome (PCOS) is an independent risk factor for adverse birth outcomes in the offspring of affected women. Here, we investigate the association of PCOS with birth outcomes in the offspring of women with PCOS overall and by potential confounders. This systematic review and meta-analysis included 73 studies and 92,881 offspring of women with and without PCOS from inception until 13th July 2022. We report that mothers with PCOS are younger and have higher body mass index (BMI) around conception and have greater gestational weight gain. The odds of preterm birth, fetal growth restriction and low birth weight are higher and mean birthweight is lower in PCOS of which a lower mean birthweight and a higher small for gestational age are probably independent of BMI. This work informed the recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome, emphasizing that PCOS status should be captured at pregnancy to identify risk and improve birth outcomes in the offspring.

Date: 2024
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DOI: 10.1038/s41467-024-49752-6

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