Barbed arrow-like structure membrane with ultra-high rectification coefficient enables ultra-fast, highly-sensitive lateral-flow assay of cTnI

Juanhua Li, Yiren Liu, Tianyu Wu, Zihan Xiao, Jianhang Du, Hongrui Liang, Cuiping Zhou and Jianhua Zhou ()
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Juanhua Li: Shenzhen Campus of Sun Yat-sen University
Yiren Liu: Shenzhen Campus of Sun Yat-sen University
Tianyu Wu: Shenzhen Campus of Sun Yat-sen University
Zihan Xiao: Shenzhen Campus of Sun Yat-sen University
Jianhang Du: the Eighth Affiliated Hospital of Sun Yat-sen University
Hongrui Liang: Shenzhen Campus of Sun Yat-sen University
Cuiping Zhou: Southern Medical University
Jianhua Zhou: Shenzhen Campus of Sun Yat-sen University

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract Acute myocardial infarction (AMI) has become a public health disease threatening public life safety due to its high mortality. The lateral-flow assay (LFA) of a typical cardiac biomarker, troponin I (cTnI), is essential for the timely warnings of AMI. However, it is a challenge to achieve an ultra-fast and highly-sensitive assay for cTnI (hs-cTnI) using current LFA, due to the limited performance of chromatographic membranes. Here, we propose a barbed arrow-like structure membrane (BAS Mem), which enables the unidirectional, fast flow and low-residual of liquid. The liquid is rectified through the forces generated by the sidewalls of the barbed arrow-like grooves. The rectification coefficient of liquid flow on BAS Mem is 14.5 (highest to date). Using BAS Mem to replace the conventional chromatographic membrane, we prepare batches of lateral-flow strips and achieve LFA of cTnI within 240 s, with a limit of detection of 1.97 ng mL−1. The lateral-flow strips exhibit a specificity of 100%, a sensitivity of 93.3% in detecting 25 samples of suspected AMI patients. The lateral-flow strips show great performance in providing reliable results for clinical diagnosis, with the potential to provide early warnings for AMI.

Date: 2024
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DOI: 10.1038/s41467-024-49810-z

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