Hippocampal connectivity patterns echo macroscale cortical evolution in the primate brain

Nicole Eichert (), Jordan DeKraker, Amy F. D. Howard, Istvan N. Huszar, Silei Zhu, Jérôme Sallet, Karla L. Miller, Rogier B. Mars, Saad Jbabdi and Boris C. Bernhardt
Additional contact information
Nicole Eichert: University of Oxford
Jordan DeKraker: McGill University
Amy F. D. Howard: University of Oxford
Istvan N. Huszar: University of Oxford
Silei Zhu: University of Oxford
Jérôme Sallet: University of Oxford
Karla L. Miller: University of Oxford
Rogier B. Mars: University of Oxford
Saad Jbabdi: University of Oxford
Boris C. Bernhardt: McGill University

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract While the hippocampus is key for human cognitive abilities, it is also a phylogenetically old cortex and paradoxically considered evolutionarily preserved. Here, we introduce a comparative framework to quantify preservation and reconfiguration of hippocampal organisation in primate evolution, by analysing the hippocampus as an unfolded cortical surface that is geometrically matched across species. Our findings revealed an overall conservation of hippocampal macro- and micro-structure, which shows anterior-posterior and, perpendicularly, subfield-related organisational axes in both humans and macaques. However, while functional organisation in both species followed an anterior-posterior axis, we observed a marked reconfiguration in the latter across species, which mirrors a rudimentary integration of the default-mode-network in non-human primates. Here we show that microstructurally preserved regions like the hippocampus may still undergo functional reconfiguration in primate evolution, due to their embedding within heteromodal association networks.

Date: 2024
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DOI: 10.1038/s41467-024-49823-8

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