tracerDB: a crowdsourced fluorescent tracer database for target engagement analysis

Johannes Dopfer, James D. Vasta, Susanne Müller, Stefan Knapp, Matthew B. Robers and Martin P. Schwalm ()
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Johannes Dopfer: Goethe University Frankfurt
James D. Vasta: Promega Corporation
Susanne Müller: Goethe University Frankfurt
Stefan Knapp: Goethe University Frankfurt
Matthew B. Robers: Promega Corporation
Martin P. Schwalm: Goethe University Frankfurt

Nature Communications, 2024, vol. 15, issue 1, 1-5

Abstract: Abstract Investigating ligand-protein complexes is essential in the areas of chemical biology and drug discovery. However, detailed information on key reagents such as fluorescent tracers and associated data for the development of widely used bioluminescence resonance energy transfer (BRET) assays including NanoBRET, time-resolved Förster resonance energy transfer (TR-FRET) and fluorescence polarization (FP) assays are not easily accessible to the research community. We created tracerDB, a curated database of validated tracers. This resource provides an open access knowledge base and a unified system for tracer and assay validation. The database is freely available at https://www.tracerdb.org/ .

Date: 2024
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DOI: 10.1038/s41467-024-49896-5

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