Soft jamming of viral particles in nanopores

Léa Chazot-Franguiadakis, Joelle Eid, Gwendoline Delecourt, Pauline J. Kolbeck, Saskia Brugère, Bastien Molcrette, Marius Socol, Marylène Mougel, Anna Salvetti, Vincent Démery, Jean-Christophe Lacroix, Véronique Bennevault, Philippe Guégan, Martin Castelnovo and Fabien Montel ()
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Léa Chazot-Franguiadakis: Université de Lyon
Joelle Eid: Université de Montpellier
Gwendoline Delecourt: Sorbonne Université
Pauline J. Kolbeck: Université de Lyon
Saskia Brugère: Université de Lyon
Bastien Molcrette: Université de Lyon
Marius Socol: Université de Montpellier
Marylène Mougel: Université de Montpellier
Anna Salvetti: Université de Lyon, INSERM
Vincent Démery: Université de Lyon
Jean-Christophe Lacroix: CNRS
Véronique Bennevault: Sorbonne Université
Philippe Guégan: Sorbonne Université
Martin Castelnovo: Université de Lyon
Fabien Montel: Université de Lyon

Nature Communications, 2024, vol. 15, issue 1, 1-9

Abstract: Abstract Viruses have remarkable physical properties and complex interactions with their environment. However, their aggregation in confined spaces remains unexplored, although this phenomenon is of paramount importance for understanding viral infectivity. Using hydrodynamical driving and optical detection, we developed a method to detect the transport of single virus in real time through synthetic nanopores. We unveiled a jamming phenomenon specifically associated with virus confinement under flow. We showed that the interactions of viral particles with themselves and with the pore surface were critical for clog formation. Based on the detailed screening of the physical and chemical determinants, we proposed a simple dynamical model that recapitulated all the experimental observations. Our results pave the way for the study of jamming phenomena in the presence of more complex interactions.

Date: 2024
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DOI: 10.1038/s41467-024-50059-9

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