Robust trigger wave speed in Xenopus cytoplasmic extracts

Jo-Hsi Huang (), Yuping Chen, William Y. C. Huang, Saman Tabatabaee and James E. Ferrell ()
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Jo-Hsi Huang: Stanford University School of Medicine
Yuping Chen: Stanford University School of Medicine
William Y. C. Huang: Stanford University School of Medicine
Saman Tabatabaee: Stanford University School of Medicine
James E. Ferrell: Stanford University School of Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Self-regenerating trigger waves can spread rapidly through the crowded cytoplasm without diminishing in amplitude or speed, providing consistent, reliable, long-range communication. The macromolecular concentration of the cytoplasm varies in response to physiological and environmental fluctuations, raising the question of how or if trigger waves can robustly operate in the face of such fluctuations. Using Xenopus extracts, we find that mitotic and apoptotic trigger wave speeds are remarkably invariant. We derive a model that accounts for this robustness and for the eventual slowing at extremely high and low cytoplasmic concentrations. The model implies that the positive and negative effects of cytoplasmic concentration (increased reactant concentration vs. increased viscosity) are nearly precisely balanced. Accordingly, artificially maintaining a constant cytoplasmic viscosity during dilution abrogates this robustness. The robustness in trigger wave speeds may contribute to the reliability of the extremely rapid embryonic cell cycle.

Date: 2024
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DOI: 10.1038/s41467-024-50119-0

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