White-light activatable organic NIR-II luminescence nanomaterials for imaging-guided surgery

Chunbin Li, Jian Du, Guoyu Jiang, Jianye Gong, Yue Zhang, Mengfan Yao, Jianguo Wang (), Limin Wu () and Ben Zhong Tang
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Chunbin Li: Inner Mongolia University
Jian Du: The First Affiliated Hospital of Shandong First Medical University
Guoyu Jiang: Inner Mongolia University
Jianye Gong: Inner Mongolia University
Yue Zhang: Inner Mongolia University
Mengfan Yao: Inner Mongolia University
Jianguo Wang: Inner Mongolia University
Limin Wu: Inner Mongolia University
Ben Zhong Tang: The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen)

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract While second near-infrared (NIR-II) fluorescence imaging is a promising tool for real-time surveillance of surgical operations, the previously reported organic NIR-II luminescent materials for in vivo imaging are predominantly activated by expensive lasers or X-ray with high power and poor illumination homogeneity, which significantly limits their clinical applications. Here we report a white-light activatable NIR-II organic imaging agent by taking advantages of the strong intramolecular/intermolecular D-A interactions of conjugated Y6CT molecules in nanoparticles (Y6CT-NPs), with the brightness of as high as 13315.1, which is over two times that of the brightest laser-activated NIR-II organic contrast agents reported thus far. Upon white-light activation, Y6CT-NPs can achieve not only in vivo imaging of hepatic ischemia reperfusion, but also real-time monitoring of kidney transplantation surgery. During the surgery, identification of the renal vasculature, post-reconstruction assessment of renal allograft vascular integrity, and blood supply analysis of the ureter can be vividly depicted by using Y6CT-NPs with high signal-to-noise ratios upon clinical laparoscopic LED white-light activation. Our work provides efficient molecular design guidelines towards white-light activatable imaging agent and highlights an opportunity for precision imaging theranostics.

Date: 2024
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DOI: 10.1038/s41467-024-50202-6

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