Developmental trajectories of EEG aperiodic and periodic components in children 2–44 months of age

Carol L. Wilkinson (), Lisa D. Yankowitz, Jerry Y. Chao, Rodrigo Gutiérrez, Jeff L. Rhoades, Shlomo Shinnar, Patrick L. Purdon and Charles A. Nelson
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Carol L. Wilkinson: Boston Children’s Hospital
Lisa D. Yankowitz: Boston Children’s Hospital
Jerry Y. Chao: Albert Einstein College of Medicine
Rodrigo Gutiérrez: Hospital Clínico de la Universidad de Chile
Jeff L. Rhoades: Harvard Medical School
Shlomo Shinnar: Albert Einstein College of Medicine
Patrick L. Purdon: Massachusetts General Hospital
Charles A. Nelson: Boston Children’s Hospital

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract The development of neural circuits has long-lasting effects on brain function, yet our understanding of early circuit development in humans remains limited. Here, periodic EEG power features and aperiodic components were examined from longitudinal EEGs collected from 592 healthy 2–44 month-old infants, revealing age-dependent nonlinear changes suggestive of distinct milestones in early brain maturation. Developmental changes in periodic peaks include (1) the presence and then absence of a 9-10 Hz alpha peak between 2-6 months, (2) nonlinear changes in high beta peaks (20-30 Hz) between 4-18 months, and (3) the emergence of a low beta peak (12-20 Hz) in some infants after six months of age. We hypothesized that the emergence of the low beta peak may reflect maturation of thalamocortical network development. Infant anesthesia studies observe that GABA-modulating anesthetics do not induce thalamocortical mediated frontal alpha coherence until 10-12 months of age. Using a small cohort of infants (n = 23) with EEG before and during GABA-modulating anesthesia, we provide preliminary evidence that infants with a low beta peak have higher anesthesia-induced alpha coherence compared to those without a low beta peak.

Date: 2024
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DOI: 10.1038/s41467-024-50204-4

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