Determinants of transthyretin levels and their association with adverse clinical outcomes among UK Biobank participants

Naman S. Shetty (), Mokshad Gaonkar, Nirav Patel, Akhil Pampana, Nehal Vekariya, Peng Li, Garima Arora and Pankaj Arora ()
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Naman S. Shetty: Massachusetts General Hospital
Mokshad Gaonkar: University of Alabama at Birmingham
Nirav Patel: University of Alabama at Birmingham
Akhil Pampana: University of Alabama at Birmingham
Nehal Vekariya: University of Alabama at Birmingham
Peng Li: University of Alabama at Birmingham
Garima Arora: University of Alabama at Birmingham
Pankaj Arora: University of Alabama at Birmingham

Nature Communications, 2024, vol. 15, issue 1, 1-7

Abstract: Abstract Transthyretin is a transport protein whose misfolding has been implicated in the development of cardiac amyloidosis. Here, we examine the clinical correlates of transthyretin levels, the differences in transthyretin levels according to the pathogenic V142I TTR variant carrier status, and the association of transthyretin levels with outcomes among 35,206 UK Biobank participants who underwent plasma profiling and were free from prevalent cardiovascular disease and chronic renal disease. Transthyretin levels are lower in females, decrease with increasing C-reactive protein levels, and increase with body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, albumin levels, triglyceride levels, and creatinine levels. V142I non-carriers [n = 35,167, mean: −0.1 (0.3)] have higher adjusted transthyretin levels compared with the carriers [n = 39, mean: −0.5 (0.3)] (p:

Date: 2024
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DOI: 10.1038/s41467-024-50231-1

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