Membrane protein MHZ3 regulates the on-off switch of ethylene signaling in rice

Xin-Kai Li, Yi-Hua Huang, Rui Zhao, Wu-Qiang Cao, Long Lu, Jia-Qi Han, Yang Zhou, Xun Zhang, Wen-Ai Wu, Jian-Jun Tao, Wei Wei, Wan-Ke Zhang, Shou-Yi Chen, Biao Ma, He Zhao (), Cui-Cui Yin () and Jin-Song Zhang ()
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Xin-Kai Li: Chinese Academy of Sciences
Yi-Hua Huang: Chinese Academy of Sciences
Rui Zhao: Chinese Academy of Sciences
Wu-Qiang Cao: Chinese Academy of Sciences
Long Lu: Fujian Agriculture and Forestry University
Jia-Qi Han: Chinese Academy of Sciences
Yang Zhou: Chinese Academy of Sciences
Xun Zhang: Chinese Academy of Sciences
Wen-Ai Wu: Chinese Academy of Sciences
Jian-Jun Tao: Chinese Academy of Sciences
Wei Wei: Chinese Academy of Sciences
Wan-Ke Zhang: Chinese Academy of Sciences
Shou-Yi Chen: Chinese Academy of Sciences
Biao Ma: South China Agricultural University
He Zhao: University of East Anglia
Cui-Cui Yin: Chinese Academy of Sciences
Jin-Song Zhang: Chinese Academy of Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Ethylene regulates plant growth, development, and stress adaptation. However, the early signaling events following ethylene perception, particularly in the regulation of ethylene receptor/CTRs (CONSTITUTIVE TRIPLE RESPONSE) complex, remains less understood. Here, utilizing the rapid phospho-shift of rice OsCTR2 in response to ethylene as a sensitive readout for signal activation, we revealed that MHZ3, previously identified as a stabilizer of ETHYLENE INSENSITIVE 2 (OsEIN2), is crucial for maintaining OsCTR2 phosphorylation. Genetically, both functional MHZ3 and ethylene receptors prove essential for OsCTR2 phosphorylation. MHZ3 physically interacts with both subfamily I and II ethylene receptors, e.g., OsERS2 and OsETR2 respectively, stabilizing their association with OsCTR2 and thereby maintaining OsCTR2 activity. Ethylene treatment disrupts the interactions within the protein complex MHZ3/receptors/OsCTR2, reducing OsCTR2 phosphorylation and initiating downstream signaling. Our study unveils the dual role of MHZ3 in fine-tuning ethylene signaling activation, providing insights into the initial stages of the ethylene signaling cascade.

Date: 2024
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DOI: 10.1038/s41467-024-50290-4

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