Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults

Alfred Pozarickij, Wei Gan, Kuang Lin, Robert Clarke, Zammy Fairhurst-Hunter, Masaru Koido, Masahiro Kanai, Yukinori Okada, Yoichiro Kamatani, Derrick Bennett, Huaidong Du, Yiping Chen, Ling Yang, Daniel Avery, Yu Guo, Min Yu, Canqing Yu, Dan Schmidt Valle, Jun Lv, Junshi Chen, Richard Peto, Rory Collins, Liming Li (), Zhengming Chen, Iona Y. Millwood and Robin G. Walters ()
Additional contact information
Alfred Pozarickij: University of Oxford
Wei Gan: University of Oxford
Kuang Lin: University of Oxford
Robert Clarke: University of Oxford
Zammy Fairhurst-Hunter: University of Oxford
Masaru Koido: The University of Tokyo
Masahiro Kanai: Massachusetts General Hospital
Yukinori Okada: Osaka University Graduate School of Medicine
Yoichiro Kamatani: The University of Tokyo
Derrick Bennett: University of Oxford
Huaidong Du: University of Oxford
Yiping Chen: University of Oxford
Ling Yang: University of Oxford
Daniel Avery: University of Oxford
Yu Guo: Chinese Academy of Medical Sciences
Min Yu: Zhejiang CDC
Canqing Yu: Peking University
Dan Schmidt Valle: University of Oxford
Jun Lv: Peking University
Junshi Chen: China National Center For Food Safety Risk Assessment
Richard Peto: University of Oxford
Rory Collins: University of Oxford
Liming Li: Peking University
Zhengming Chen: University of Oxford
Iona Y. Millwood: University of Oxford
Robin G. Walters: University of Oxford

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Elevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations. Despite strong genetic correlations between populations, we identified appreciably higher heritability and larger variant effect sizes in Chinese compared with European or Japanese ancestry populations. Using instruments derived from these GWAS, multivariable Mendelian randomisation demonstrated that BP traits contribute differently to the causal associations of BP with CVD. In particular, only pulse pressure was independently causally associated with carotid plaque. These findings reinforce the need for studies in diverse populations to understand the genetic determinants of BP traits and their roles in disease risk.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-50297-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50297-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-50297-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().