Plasmonic trimers designed as SERS-active chemical traps for subtyping of lung tumors

Xing Zhao, Xiaojing Liu, Dexiang Chen, Guodong Shi, Guoqun Li, Xiao Tang, Xiangnan Zhu, Mingze Li, Lei Yao, Yunjia Wei, Wenzhe Song, Zixuan Sun, Xingce Fan, Zhixin Zhou, Teng Qiu () and Qi Hao ()
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Xing Zhao: Southeast University
Xiaojing Liu: the Affiliated Hospital of Qingdao University
Dexiang Chen: Southeast University
Guodong Shi: the Affiliated Hospital of Qingdao University
Guoqun Li: Southeast University
Xiao Tang: Southeast University
Xiangnan Zhu: Southeast University
Mingze Li: Southeast University
Lei Yao: Southeast University
Yunjia Wei: Southeast University
Wenzhe Song: Southeast University
Zixuan Sun: Southeast University
Xingce Fan: Southeast University
Zhixin Zhou: Southeast University
Teng Qiu: Southeast University
Qi Hao: Southeast University

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract Plasmonic materials can generate strong electromagnetic fields to boost the Raman scattering of surrounding molecules, known as surface-enhanced Raman scattering. However, these electromagnetic fields are heterogeneous, with only molecules located at the ‘hotspots’, which account for ≈ 1% of the surface area, experiencing efficient enhancement. Herein, we propose patterned plasmonic trimers, consisting of a pair of plasmonic dimers at the bilateral sides and a trap particle positioned in between, to address this challenge. The trimer configuration selectively directs probe molecules to the central traps where ‘hotspots’ are located through chemical affinity, ensuring a precise spatial overlap between the probes and the location of maximum field enhancement. We investigate the Raman enhancement of the Au@Al2O3-Au-Au@Al2O3 trimers, achieving a detection limit of 10−14 M of 4-methylbenzenethiol, 4-mercaptopyridine, and 4-aminothiophenol. Moreover, single-molecule SERS sensitivity is demonstrated by a bi-analyte method. Benefiting from this sensitivity, our approach is employed for the early detection of lung tumors using fresh tissues. Our findings suggest that this approach is sensitive to adenocarcinoma but not to squamous carcinoma or benign cases, offering insights into the differentiation between lung tumor subtypes.

Date: 2024
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DOI: 10.1038/s41467-024-50321-0

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