Non-human primate model of long-COVID identifies immune associates of hyperglycemia

Clovis S. Palmer (), Chrysostomos Perdios, Mohamed Abdel-Mohsen, Joseph Mudd, Prasun K. Datta, Nicholas J. Maness, Gabrielle Lehmicke, Nadia Golden, Linh Hellmers, Carol Coyne, Kristyn Moore Green, Cecily Midkiff, Kelsey Williams, Rafael Tiburcio, Marissa Fahlberg, Kyndal Boykin, Carys Kenway, Kasi Russell-Lodrigue, Angela Birnbaum, Rudolf Bohm, Robert Blair, Jason P. Dufour, Tracy Fischer, Ahmad A. Saied and Jay Rappaport ()
Additional contact information
Clovis S. Palmer: Tulane National Primate Research Center
Chrysostomos Perdios: Tulane National Primate Research Center
Mohamed Abdel-Mohsen: The Wistar Institute
Joseph Mudd: Tulane National Primate Research Center
Prasun K. Datta: Tulane National Primate Research Center
Nicholas J. Maness: Tulane National Primate Research Center
Gabrielle Lehmicke: Tulane National Primate Research Center
Nadia Golden: Tulane National Primate Research Center
Linh Hellmers: Tulane National Primate Research Center
Carol Coyne: Tulane National Primate Research Center
Kristyn Moore Green: Tulane National Primate Research Center
Cecily Midkiff: Tulane National Primate Research Center
Kelsey Williams: Tulane National Primate Research Center
Rafael Tiburcio: University of San Francisco
Marissa Fahlberg: Tulane National Primate Research Center
Kyndal Boykin: Tulane National Primate Research Center
Carys Kenway: Tulane National Primate Research Center
Kasi Russell-Lodrigue: Tulane National Primate Research Center
Angela Birnbaum: Tulane National Primate Research Center
Rudolf Bohm: Oregon Health and Science University
Robert Blair: Tulane National Primate Research Center
Jason P. Dufour: Tulane National Primate Research Center
Tracy Fischer: Tulane National Primate Research Center
Ahmad A. Saied: Tulane National Primate Research Center
Jay Rappaport: Tulane National Primate Research Center

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Hyperglycemia, and exacerbation of pre-existing deficits in glucose metabolism, are manifestations of the post-acute sequelae of SARS-CoV-2. Our understanding of metabolic decline after acute COVID-19 remains unclear due to the lack of animal models. Here, we report a non-human primate model of metabolic post-acute sequelae of SARS-CoV-2 using SARS-CoV-2 infected African green monkeys. Using this model, we identify a dysregulated blood chemokine signature during acute COVID-19 that correlates with elevated and persistent hyperglycemia four months post-infection. Hyperglycemia also correlates with liver glycogen levels, but there is no evidence of substantial long-term SARS-CoV-2 replication in the liver and pancreas. Finally, we report a favorable glycemic effect of the SARS-CoV-2 mRNA vaccine, administered on day 4 post-infection. Together, these data suggest that the African green monkey model exhibits important similarities to humans and can be utilized to assess therapeutic candidates to combat COVID-related metabolic defects.

Date: 2024
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DOI: 10.1038/s41467-024-50339-4

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