Modifiable lifestyle factors and the risk of post-COVID-19 multisystem sequelae, hospitalization, and death

Yunhe Wang, Binbin Su, Marta Alcalde-Herraiz, Nicola L. Barclay, Yaohua Tian, Chunxiao Li, Nicholas J. Wareham, Roger Paredes, Junqing Xie () and Daniel Prieto-Alhambra
Additional contact information
Yunhe Wang: University of Oxford
Binbin Su: Chinese Academy of Medical Sciences/Peking Union Medical College
Marta Alcalde-Herraiz: NDORMS, University of Oxford
Nicola L. Barclay: NDORMS, University of Oxford
Yaohua Tian: Huazhong University of Science and Technology
Chunxiao Li: University of Cambridge
Nicholas J. Wareham: University of Cambridge
Roger Paredes: Hospital Universitari Germans Trias i Pujol
Junqing Xie: NDORMS, University of Oxford
Daniel Prieto-Alhambra: NDORMS, University of Oxford

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Effective prevention strategies for post-COVID complications are crucial for patients, clinicians, and policy makers to mitigate their cumulative burden. This study evaluated the association of modifiable lifestyle factors (smoking, alcohol intake, BMI, physical activity, sedentary time, sleep duration, and dietary habits) with COVID-19 multisystem sequelae, death, and hospitalization in the UK Biobank cohort (n = 68,896). A favorable lifestyle (6-10 healthy factors; 46.4%) was associated with a 36% lower risk of multisystem sequelae (HR, 0.64; 95% CI, 0.58-0.69; ARR at 210 days, 7.08%; 95% CI, 5.98-8.09) compared to an unfavorable lifestyle (0-4 factors; 12.3%). Risk reductions spanned all 10 organ systems, including cardiovascular, coagulation, metabolic, gastrointestinal, kidney, mental health, musculoskeletal, respiratory disorders, and fatigue. This beneficial effect was largely attributable to direct lifestyle impacts independent of corresponding pre-infection comorbidities (71% for any sequelae). A favorable lifestyle was also related to the risk of post-COVID death (HR 0.59, 0.52-0.66) and hospitalization (HR 0.78, 0.73-0.84). These associations persisted across acute and post-acute infection phases, irrespective of hospitalization status, vaccination, or SARS-CoV-2 variant. These findings underscore the clinical and public health importance of adhering to a healthy lifestyle in mitigating long-term COVID-19 adverse impacts and enhancing future pandemic preparedness.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-50495-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50495-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-50495-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().