Pt nanoshells with a high NIR-II photothermal conversion efficiency mediates multimodal neuromodulation against ventricular arrhythmias

Chenlu Wang, Liping Zhou, Chengzhe Liu, Jiaming Qiao, Xinrui Han, Luyang Wang, Yaxi Liu, Bi Xu, Qinfang Qiu, Zizhuo Zhang, Jiale Wang, Xiaoya Zhou (), Mengqi Zeng, Lilei Yu () and Lei Fu ()
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Chenlu Wang: Wuhan University
Liping Zhou: Renmin Hospital of Wuhan University
Chengzhe Liu: Renmin Hospital of Wuhan University
Jiaming Qiao: Renmin Hospital of Wuhan University
Xinrui Han: Renmin Hospital of Wuhan University
Luyang Wang: Wuhan University
Yaxi Liu: Wuhan University
Bi Xu: Wuhan University
Qinfang Qiu: Renmin Hospital of Wuhan University
Zizhuo Zhang: Renmin Hospital of Wuhan University
Jiale Wang: Renmin Hospital of Wuhan University
Xiaoya Zhou: Renmin Hospital of Wuhan University
Mengqi Zeng: Wuhan University
Lilei Yu: Renmin Hospital of Wuhan University
Lei Fu: Wuhan University

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Autonomic nervous system disorders play a pivotal role in the pathophysiology of cardiovascular diseases. Regulating it is essential for preventing and treating acute ventricular arrhythmias (VAs). Photothermal neuromodulation is a nonimplanted technique, but the response temperature ranges of transient receptor potential vanilloid 1 (TRPV1) and TWIK-related K+ Channel 1 (TREK1) exhibit differences while being closely aligned, and the acute nature of VAs require that it must be rapid and precise. However, the low photothermal conversion efficiency (PCE) still poses limitations in achieving rapid and precise treatment. Here, we achieve a nearly perfect blackbody absorption and a high PCE in the second near infrared (NIR-II) window (73.7% at 1064 nm) via a Pt nanoparticle shell (PtNP-shell). By precisely manipulating the photothermal effect, we successfully achieve rapid and precise multimodal neuromodulation encompassing neural activation (41.0–42.9 °C) and inhibition (45.0–46.9 °C) in a male canine model. The NIR-II photothermal modulation additionally achieves multimodal reversible autonomic modulation and confers protection against acute VAs associated with myocardial ischemia and reperfusion injury in interventional therapy.

Date: 2024
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DOI: 10.1038/s41467-024-50557-w

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