Electrochemical deoxygenative amination of stabilized alkyl radicals from activated alcohols

Jia Xu, Yilin Liu, Qing Wang, Xiangzhang Tao, Shengyang Ni, Weigang Zhang, Lei Yu, Yi Pan and Yi Wang ()
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Jia Xu: Nanjing University
Yilin Liu: Nanjing University
Qing Wang: Nanjing University
Xiangzhang Tao: Nanjing University
Shengyang Ni: Nanjing University
Weigang Zhang: Nanjing University
Lei Yu: Nanjing University
Yi Pan: Nanjing University
Yi Wang: Nanjing University

Nature Communications, 2024, vol. 15, issue 1, 1-9

Abstract: Abstract Alkylamine structures represent one of the most functional and widely used in organic synthesis and drug design. However, the general methods for the functionalization of the shielded and deshielded alkyl radicals remain elusive. Here, we report a general deoxygenative amination protocol using alcohol-derived carbazates and nitrobenzene under electrochemical conditions. A range of primary, secondary, and tertiary alkylamines are obtained. This practical procedure can be scaled up through electrochemical continuous flow technique.

Date: 2024
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DOI: 10.1038/s41467-024-50596-3

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