Biocatalysis enables the scalable conversion of biobased furans into various furfurylamines

Pritam Giri, Seonga Lim, Taresh P. Khobragade, Amol D. Pagar, Mahesh D. Patil, Sharad Sarak, Hyunwoo Jeon, Sangwoo Joo, Younghwan Goh, Seohee Jung, Yu-Jeong Jang, Seung Beom Choi, Ye Chan Kim, Taek Jin Kang, Yong-Seok Heo () and Hyungdon Yun ()
Additional contact information
Pritam Giri: Konkuk University
Seonga Lim: Konkuk University
Taresh P. Khobragade: Konkuk University
Amol D. Pagar: Konkuk University
Mahesh D. Patil: CSIR- National Chemical Laboratory
Sharad Sarak: Konkuk University
Hyunwoo Jeon: Konkuk University
Sangwoo Joo: Konkuk University
Younghwan Goh: Konkuk University
Seohee Jung: Konkuk University
Yu-Jeong Jang: Konkuk University
Seung Beom Choi: Konkuk University
Ye Chan Kim: Seoul National University
Taek Jin Kang: Dongguk University
Yong-Seok Heo: Konkuk University
Hyungdon Yun: Konkuk University

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract Biobased furans have emerged as chemical building blocks for the development of materials because of their diverse scaffolds and as they can be directly prepared from sugars. However, selective, efficient, and cost-effective scalable conversion of biobased furans remains elusive. Here, we report a robust transaminase (TA) from Shimia marina (SMTA) that enables the scalable amination of biobased furanaldehydes with high activity and broad substrate specificity. Crystallographic and mutagenesis analyses provide mechanistic insights and a structural basis for understanding SMTA, which enables a higher substrate conversion. The enzymatic cascade process established in this study allows one-pot synthesis of 2,5-bis(aminomethyl)furan (BAMF) and 5-(aminomethyl)furan-2-carboxylic acid from 5-hydroxymethylfurfural. The biosynthesis of various furfurylamines, including a one-pot cascade reaction for BAMF generation using whole cells, demonstrates their practical application in the pharmaceutical and polymer industries.

Date: 2024
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DOI: 10.1038/s41467-024-50637-x

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