A male mouse model for metabolic dysfunction-associated steatotic liver disease and hepatocellular carcinoma

Byung-Kwan Jeong, Won-Il Choi, Wonsuk Choi (), Jieun Moon, Won Hee Lee, Chan Choi, In Young Choi, Sang-Hyun Lee, Jung Kuk Kim, Young Seok Ju, Pilhan Kim, Young-Ah Moon, Jun Yong Park () and Hail Kim ()
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Byung-Kwan Jeong: KAIST
Won-Il Choi: KAIST
Wonsuk Choi: Chonnam National University Medical School
Jieun Moon: KAIST
Won Hee Lee: KAIST
Chan Choi: Chonnam National University Medical School
In Young Choi: Hanmi Pharmaceutical Co. Ltd
Sang-Hyun Lee: Hanmi Pharmaceutical Co. Ltd
Jung Kuk Kim: Hanmi Pharmaceutical Co. Ltd
Young Seok Ju: KAIST
Pilhan Kim: KAIST
Young-Ah Moon: Inha University College of Medicine
Jun Yong Park: Severance Hospital
Hail Kim: KAIST

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract The lack of an appropriate preclinical model of metabolic dysfunction-associated steatotic liver disease (MASLD) that recapitulates the whole disease spectrum impedes exploration of disease pathophysiology and the development of effective treatment strategies. Here, we develop a mouse model (Streptozotocin with high-fat diet, STZ + HFD) that gradually develops fatty liver, metabolic dysfunction-associated steatohepatitis (MASH), hepatic fibrosis, and hepatocellular carcinoma (HCC) in the context of metabolic dysfunction. The hepatic transcriptomic features of STZ + HFD mice closely reflect those of patients with obesity accompanying type 2 diabetes mellitus, MASH, and MASLD-related HCC. Dietary changes and tirzepatide administration alleviate MASH, hepatic fibrosis, and hepatic tumorigenesis in STZ + HFD mice. In conclusion, a murine model recapitulating the main histopathologic, transcriptomic, and metabolic alterations observed in MASLD patients is successfully established.

Date: 2024
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DOI: 10.1038/s41467-024-50660-y

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