Biomimetic synergistic effect of redox site and Lewis acid for construction of efficient artificial enzyme

Haibin Si, Dexin Du, Chengcheng Jiao, Yan Sun, Lu Li () and Bo Tang
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Haibin Si: Shandong Normal University
Dexin Du: Shandong Normal University
Chengcheng Jiao: Shandong Normal University
Yan Sun: Shandong Normal University
Lu Li: Shandong Normal University

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract In enzymatic catalysis, the redox site and Lewis acid are the two main roles played by metal to assist amino acids. However, the reported enzyme mimics only focus on the redox-active metal as redox site, while the redox-inert metal as Lewis acid has, to the best of our knowledge, not been studied, presenting a bottleneck of enzyme mimics construction. Based on this, a series of highly efficient MxV2O5·nH2O peroxidase mimics with vanadium as redox site and alkaline-earth metal ion (M2+) as Lewis acid are reported. Experimental results and theoretical calculations indicate the peroxidase-mimicking activity of MxV2O5·nH2O show a periodic change with the Lewis acidity (ion potential) of M2+, revealing the mechanism of redox-inert M2+ regulating electron transfer of V-O through non-covalent polarization and thus promoting H2O2 adsorbate dissociation. The biomimetic synergetic effect of redox site and Lewis acid is expected to provide an inspiration for design of enzyme mimics.

Date: 2024
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DOI: 10.1038/s41467-024-50687-1

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