Adult neurogenesis improves spatial information encoding in the mouse hippocampus

M. Agustina Frechou, Sunaina S. Martin, Kelsey D. McDermott, Evan A. Huaman, Şölen Gökhan, Wolfgang A. Tomé, Ruben Coen-Cagli and J. Tiago Gonçalves ()
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M. Agustina Frechou: Albert Einstein College of Medicine
Sunaina S. Martin: Albert Einstein College of Medicine
Kelsey D. McDermott: Albert Einstein College of Medicine
Evan A. Huaman: Albert Einstein College of Medicine
Şölen Gökhan: Albert Einstein College of Medicine
Wolfgang A. Tomé: Albert Einstein College of Medicine
Ruben Coen-Cagli: Albert Einstein College of Medicine
J. Tiago Gonçalves: Albert Einstein College of Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Adult neurogenesis is a unique form of neuronal plasticity in which newly generated neurons are integrated into the adult dentate gyrus in a process that is modulated by environmental stimuli. Adult-born neurons can contribute to spatial memory, but it is unknown whether they alter neural representations of space in the hippocampus. Using in vivo two-photon calcium imaging, we find that male and female mice previously housed in an enriched environment, which triggers an increase in neurogenesis, have increased spatial information encoding in the dentate gyrus. Ablating adult neurogenesis blocks the effect of enrichment and lowers spatial information, as does the chemogenetic silencing of adult-born neurons. Both ablating neurogenesis and silencing adult-born neurons decreases the calcium activity of dentate gyrus neurons, resulting in a decreased amplitude of place-specific responses. These findings are in contrast with previous studies that suggested a predominantly inhibitory action for adult-born neurons. We propose that adult neurogenesis improves representations of space by increasing the gain of dentate gyrus neurons and thereby improving their ability to tune to spatial features. This mechanism may mediate the beneficial effects of environmental enrichment on spatial learning and memory.

Date: 2024
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DOI: 10.1038/s41467-024-50699-x

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