A conserved oomycete effector RxLR23 triggers plant defense responses by targeting ERD15La to release NbNAC68

Hui Sheng, Congcong Ai, Cancan Yang, Chunyuan Zhu, Zhe Meng, Fengzhi Wu, Xiaodan Wang, Daolong Dou, Paul F. Morris and Xiuguo Zhang ()
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Hui Sheng: Shandong Agricultural University
Congcong Ai: Shandong Agricultural University
Cancan Yang: Shandong Agricultural University
Chunyuan Zhu: Shandong Agricultural University
Zhe Meng: Shandong Normal University
Fengzhi Wu: Northeast Agricultural University
Xiaodan Wang: China Agricultural University
Daolong Dou: Nanjing Agricultural University
Paul F. Morris: Bowling Green State University
Xiuguo Zhang: Shandong Agricultural University

Nature Communications, 2024, vol. 15, issue 1, 1-23

Abstract: Abstract Oomycete pathogens deliver many effectors to enhance virulence or suppress plant immunity. Plant immune networks are interconnected, in which a few effectors can trigger a strong defense response when recognized by immunity-related proteins. How effectors activate plant defense response remains poorly understood. Here we report Phytophthora capsici effector RxLR23KM can induce plant cell death and plant immunity. RxLR23KM specifically binds to ERD15La, a regulator of abscisic acid and salicylic acid pathway, and the binding intensity depends on the amino acid residues (K93 and M320). NbNAC68, a downstream protein of ERD15La, can stimulate plant immunity that is compromised after binding with ERD15La. Silencing of NbNAC68 substantially prevents the activation of plant defense response. RxLR23KM binds to ERD15La, releasing NbNAC68 to activate plant immunity. These findings highlight a strategy of plant defense response that ERD15La as a central regulator coordinates RxLR23KM to regulate NbNAC68-triggered plant immunity.

Date: 2024
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DOI: 10.1038/s41467-024-50782-3

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