Genome-wide variation study and inter-tissue communication analysis unveil regulatory mechanisms of egg-laying performance in chickens

Dandan Wang, Lizhi Tan, Yihao Zhi, Lina Bu, Yangyang Wang, Zhang Wang, Yulong Guo, Weihua Tian, Chunlin Xu, Donghua Li, Zhuanjian Li, Ruirui Jiang, Ruili Han, Guoxi Li, Yongqiang Wang, Dong Xia, Yadong Tian, Ian C. Dunn, Xiaoxiang Hu, Hong Li (), Yiqiang Zhao (), Xiangtao Kang () and Xiaojun Liu ()
Additional contact information
Dandan Wang: Henan Agricultural University
Lizhi Tan: China Agricultural University
Yihao Zhi: Henan Agricultural University
Lina Bu: China Agricultural University
Yangyang Wang: Henan Agricultural University
Zhang Wang: Henan Agricultural University
Yulong Guo: Henan Agricultural University
Weihua Tian: Henan Agricultural University
Chunlin Xu: Henan Sangao Agriculture and Animal Husbandry Co, Ltd
Donghua Li: Henan Agricultural University
Zhuanjian Li: Henan Agricultural University
Ruirui Jiang: Henan Agricultural University
Ruili Han: Henan Agricultural University
Guoxi Li: Henan Agricultural University
Yongqiang Wang: Henan Institute of Science and Technology
Dong Xia: The Royal Veterinary College
Yadong Tian: Henan Agricultural University
Ian C. Dunn: University of Edinburgh
Xiaoxiang Hu: China Agricultural University
Hong Li: Henan Agricultural University
Yiqiang Zhao: China Agricultural University
Xiangtao Kang: Henan Agricultural University
Xiaojun Liu: Henan Agricultural University

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Egg-laying performance is of great economic importance in poultry, but the underlying genetic mechanisms are still elusive. In this work, we conduct a multi-omics and multi-tissue integrative study in hens with distinct egg production, to detect the hub candidate genes and construct hub molecular networks contributing to egg-laying phenotypic differences. We identifiy three hub candidate genes as egg-laying facilitators: TFPI2, which promotes the GnRH secretion in hypothalamic neuron cells; CAMK2D, which promotes the FSHβ and LHβ secretion in pituitary cells; and OSTN, which promotes granulosa cell proliferation and the synthesis of sex steroid hormones. We reveal key endocrine factors involving egg production by inter-tissue crosstalk analysis, and demonstrate that both a hepatokine, APOA4, and an adipokine, ANGPTL2, could increase egg production by inter-tissue communication with hypothalamic-pituitary-ovarian axis. Together, These results reveal the molecular mechanisms of multi-tissue coordinative regulation of chicken egg-laying performance and provide key insights to avian reproductive regulation.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-50809-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50809-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-50809-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().