Reprogramming the myocardial infarction microenvironment with melanin-based composite nanomedicines in mice

Yamei Liu, Shuya Wang, Jiaxiong Zhang, Quan Sun, Yi Xiao, Jing Chen, Meilian Yao, Guogang Zhang, Qun Huang, Tianjiao Zhao, Qiong Huang, Xiaojing Shi, Can Feng, Kelong Ai () and Yongping Bai ()
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Yamei Liu: Central South University
Shuya Wang: Central South University
Jiaxiong Zhang: Central South University
Quan Sun: Central South University
Yi Xiao: Central South University
Jing Chen: Central South University
Meilian Yao: Central South University
Guogang Zhang: Central South University
Qun Huang: Hunan Provincial Maternal and Child Health Care Hospital
Tianjiao Zhao: Central South University
Qiong Huang: Central South University
Xiaojing Shi: Central South University
Can Feng: Central South University
Kelong Ai: Central South University
Yongping Bai: Central South University

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Myocardial infarction (MI) has a 5-year mortality rate of more than 50% due to the lack of effective treatments. Interactions between cardiomyocytes and the MI microenvironment (MIM) can determine the progression and fate of infarcted myocardial tissue. Here, a specially designed Melanin-based composite nanomedicines (MCN) is developed to effectively treat MI by reprogramming the MIM. MCN is a nanocomposite composed of polydopamine (P), Prussian blue (PB) and cerium oxide (CexOy) with a Mayuan-like structure, which reprogramming the MIM by the efficient conversion of detrimental substances (H+, reactive oxygen species, and hypoxia) into beneficial status (O2 and H2O). In coronary artery ligation and ischemia reperfusion models of male mice, intravenously injecting MCN specifically targets the damaged area, resulting in restoration of cardiac function. With its promising therapeutic effects, MCN constitutes a new agent for MI treatment and demonstrates potential for clinical application.

Date: 2024
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DOI: 10.1038/s41467-024-50854-4

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