Cxcr4 regulates a pool of adipocyte progenitors and contributes to adiposity in a sex-dependent manner

Benjamin M. Steiner, Abigail M. Benvie, Derek Lee, Yuwei Jiang and Daniel C. Berry ()
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Benjamin M. Steiner: Cornell University
Abigail M. Benvie: Cornell University
Derek Lee: Cornell University
Yuwei Jiang: University of Illinois at Chicago
Daniel C. Berry: Cornell University

Nature Communications, 2024, vol. 15, issue 1, 1-21

Abstract: Abstract Sex steroids modulate the distribution of mammalian white adipose tissues. Moreover, WAT remodeling requires adipocyte progenitor cells. Nevertheless, the sex-dependent mechanisms regulating adipocyte progenitors remain undetermined. Here, we uncover Cxcr4 acting in a sexually dimorphic manner to affect a pool of proliferating cells leading to restriction of female fat mass. We find that deletion of Cxcr4 in Pparγ-expressing cells results in female, not male, lipodystrophy, which cannot be restored by high-fat diet consumption. Additionally, Cxcr4 deletion is associated with a loss of a pool of proliferating adipocyte progenitors. Cxcr4 loss is accompanied by the upregulation of estrogen receptor alpha in adipose-derived PPARγ-labelled cells related to estradiol hypersensitivity and stalled adipogenesis. Estrogen removal or administration of antiestrogens restores WAT accumulation and dynamics of adipose-derived cells in Cxcr4-deficient mice. These findings implicate Cxcr4 as a female adipogenic rheostat, which may inform strategies to target female adiposity.

Date: 2024
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DOI: 10.1038/s41467-024-50985-8

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