Multisensory gamma stimulation mitigates the effects of demyelination induced by cuprizone in male mice

Daniela Rodrigues-Amorim, P. Lorenzo Bozzelli, TaeHyun Kim, Liwang Liu, Oliver Gibson, Cheng-Yi Yang, Mitchell H. Murdock, Fabiola Galiana-Melendez, Brooke Schatz, Alexis Davison, Md Rezaul Islam, Dong Shin Park, Ravikiran M. Raju, Fatema Abdurrob, Alissa J. Nelson, Jian Min Ren, Vicky Yang, Matthew P. Stokes and Li-Huei Tsai ()
Additional contact information
Daniela Rodrigues-Amorim: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
P. Lorenzo Bozzelli: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
TaeHyun Kim: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Liwang Liu: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Oliver Gibson: Ltd
Cheng-Yi Yang: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Mitchell H. Murdock: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Fabiola Galiana-Melendez: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Brooke Schatz: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Alexis Davison: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Md Rezaul Islam: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Dong Shin Park: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Ravikiran M. Raju: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Fatema Abdurrob: Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Alissa J. Nelson: Cell Signaling Technology
Jian Min Ren: Cell Signaling Technology
Vicky Yang: Cell Signaling Technology
Matthew P. Stokes: Cell Signaling Technology
Li-Huei Tsai: Picower Institute for Learning and Memory, Massachusetts Institute of Technology

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Demyelination is a common pathological feature in a wide range of diseases, characterized by the loss of myelin sheath and myelin-supporting oligodendrocytes. These losses lead to impaired axonal function, increased vulnerability of axons to damage, and result in significant brain atrophy and neuro-axonal degeneration. Multiple pathomolecular processes contribute to neuroinflammation, oligodendrocyte cell death, and progressive neuronal dysfunction. In this study, we use the cuprizone mouse model of demyelination to investigate long-term non-invasive gamma entrainment using sensory stimulation as a potential therapeutic intervention for promoting myelination and reducing neuroinflammation in male mice. Here, we show that multisensory gamma stimulation mitigates demyelination, promotes oligodendrogenesis, preserves functional integrity and synaptic plasticity, attenuates oligodendrocyte ferroptosis-induced cell death, and reduces brain inflammation. Thus, the protective effects of multisensory gamma stimulation on myelin and anti-neuroinflammatory properties support its potential as a therapeutic approach for demyelinating disorders.

Date: 2024
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DOI: 10.1038/s41467-024-51003-7

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