A physical derivation of high-flux ion transport in biological channel via quantum ion coherence

Yue Wang, Yixiao Hu, Jian-Ping Guo, Jun Gao (), Bo Song () and Lei Jiang
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Yue Wang: Huazhong Agricultural University
Yixiao Hu: Huazhong Agricultural University
Jian-Ping Guo: Huazhong Agricultural University
Jun Gao: Huazhong Agricultural University
Bo Song: University of Shanghai for Science and Technology
Lei Jiang: Chinese Academy of Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-8

Abstract: Abstract Biological ion channels usually conduct the high-flux transport of 107 ~ 108 ions·s−1; however, the underlying mechanism is still lacking. Here, by applying the KcsA potassium channel as a typical example, and performing multitimescale molecular dynamics simulations, we demonstrate that there is coherence of the K+ ions confined in biological channels, which determines transport. The coherent oscillation state of confined K+ ions with a nanosecond-level lifetime in the channel dominates each transport event, serving as the physical basis for the high flux of ~108 ions∙s−1. The coherent transfer of confined K+ ions only takes several picoseconds and has no perturbation effect on the ion coherence, acting as the directional key of transport. Such ion coherence is allowed by quantum mechanics. An increase in the coherence can significantly enhance the ion conductance. These findings provide a potential explanation from the perspective of coherence for the high-flux ion transport with ultralow energy consumption of biological channels.

Date: 2024
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DOI: 10.1038/s41467-024-51045-x

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