Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate COPD: a double-blind, parallel group, multicentre randomised clinical trial

Yumin Zhou, Fan Wu, Zhe Shi, Jie Cao, Jia Tian, Weimin Yao, Liping Wei, Fenglei Li, Shan Cai, Yao Shen, Zanfeng Wang, Huilan Zhang, Yanfan Chen, Yingyun Fu, Zhiyi He, Chun Chang, Yongliang Jiang, Shujing Chen, Changli Yang, Shuqing Yu, Heshen Tian, Qijian Cheng, Ziwen Zhao, Yinghua Ying, Yong Zhou, Shengming Liu, Zhishan Deng, Peiyu Huang, Yunzhen Zhang, Xiangwen Luo, Haiyan Zhao, Jianping Gui, Weiguang Lai, Guoping Hu, Cong Liu, Ling Su, Zhiguang Liu, Jianhui Huang, Dongxing Zhao, Nanshan Zhong and Pixin Ran ()
Additional contact information
Yumin Zhou: Guangzhou Medical University
Fan Wu: Guangzhou Medical University
Zhe Shi: Huizhou First Hospital
Jie Cao: Tianjin Medical University General Hospital
Jia Tian: The Second People’s Hospital of Hunan Province
Weimin Yao: The Second Affiliated Hospital of Guangdong Medical University
Liping Wei: The Third Affiliated Hospital of Guangzhou Medical University
Fenglei Li: Liwan Central Hospital of Guangzhou
Shan Cai: The Second Xiangya Hospital of Central South University
Yao Shen: Fudan University Pudong Medical Center
Zanfeng Wang: The First Hospital of China Medical University
Huilan Zhang: Huazhong University of Science and Technology
Yanfan Chen: The First Hospital of Wenzhou Medical University
Yingyun Fu: Shenzhen People’s Hospital
Zhiyi He: The First Hospital of Guangxi Medical University
Chun Chang: Peking University Third Hospital
Yongliang Jiang: Hunan Provincial People’s Hospital
Shujing Chen: Fudan University
Changli Yang: Wengyuan County People’s Hospital
Shuqing Yu: Lianping County Hospital of Traditional Chinese Medicine
Heshen Tian: Guangzhou Medical University
Qijian Cheng: Shanghai Jiao Tong University School of Medicine
Ziwen Zhao: Guangzhou First People’s Hospital
Yinghua Ying: The Second Affiliated Hospital of Zhejiang University School of Medicine
Yong Zhou: Zhejiang University School of Medicine
Shengming Liu: The First Affiliated Hospital of Jinan University
Zhishan Deng: Guangzhou Medical University
Peiyu Huang: Guangzhou Medical University
Yunzhen Zhang: Huizhou First Hospital
Xiangwen Luo: Lianping County Hospital of Traditional Chinese Medicine
Haiyan Zhao: Tianjin Medical University General Hospital
Jianping Gui: The Second People’s Hospital of Hunan Province
Weiguang Lai: The Affiliated Hospital of Guangdong Medical University
Guoping Hu: The Third Affiliated Hospital of Guangzhou Medical University
Cong Liu: The Second Xiangya Hospital of Central South University
Ling Su: Fudan University Pudong Medical Center
Zhiguang Liu: Hunan Provincial People’s Hospital
Jianhui Huang: Lianping County Hospital of Traditional Chinese Medicine
Dongxing Zhao: Guangzhou Medical University
Nanshan Zhong: Guangzhou Medical University
Pixin Ran: Guangzhou Medical University

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract Evidence for the treatment of patients with mild-to-moderate chronic obstructive pulmonary disease (COPD) is limited. The efficacy of N-acetylcysteine (an antioxidant and mucolytic agent) for patients with mild-to-moderate COPD is uncertain. In this multicentre, randomised, double-blind, placebo-controlled trial, we randomly assigned 968 patients with mild-to-moderate COPD to treatment with N-acetylcysteine (600 mg, twice daily) or matched placebo for two years. Eligible participants were 40-80 years of age and had mild-to-moderate COPD (forced expiratory volume in 1 second [FEV1] to forced vital capacity ratio

Date: 2024
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DOI: 10.1038/s41467-024-51079-1

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