Wrapping stem cells with wireless electrical nanopatches for traumatic brain injury therapy

Liang Wang, Jingyi Du, Qilu Liu, Dongshuang Wang, Wenhan Wang, Ming Lei, Keyi Li, Yiwei Li, Aijun Hao, Yuanhua Sang, Fan Yi, Wenjuan Zhou (), Hong Liu (), Chuanbin Mao () and Jichuan Qiu ()
Additional contact information
Liang Wang: Shandong University
Jingyi Du: School of Basic Medical Sciences, Shandong University
Qilu Liu: Shandong University
Dongshuang Wang: School of Basic Medical Sciences, Shandong University
Wenhan Wang: Shandong University
Ming Lei: Shandong University
Keyi Li: Shandong University
Yiwei Li: Shandong University
Aijun Hao: School of Basic Medical Sciences, Shandong University
Yuanhua Sang: Shandong University
Fan Yi: School of Basic Medical Sciences, Shandong University
Wenjuan Zhou: School of Basic Medical Sciences, Shandong University
Hong Liu: Shandong University
Chuanbin Mao: The Chinese University of Hong Kong, Sha Tin
Jichuan Qiu: Shandong University

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Electrical stimulation holds promise for enhancing neuronal differentiation of neural stem cells to treat traumatic brain injury. However, once the stem cells leave the stimulating material and migrate post transplantation, electrical stimulation on them is diminished. Here, we wrap the stem cells with wireless electrical nanopatches, the conductive graphene nanosheets. Under electromagnetic induction, electrical stimulation can thus be applied in-situ to individual nanopatch-wrapped stem cells on demand, stimulating their neuronal differentiation through a MAPK/ERK signaling pathway. Consequently, 41% of the nanopatch-wrapped stem cells differentiate into functional neurons in 5 days, as opposed to only 16.3% of the unwrapped ones. The brain injury male mice implanted with the nanopatch-wrapped stem cells and exposed to a rotating magnetic field 30 min/day exhibit significant recovery of brain tissues, behaviors, and cognitions, within 28 days. This study opens up an avenue to individualized electrical stimulation of transplanted stem cells for treating neurodegenerative diseases.

Date: 2024
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DOI: 10.1038/s41467-024-51098-y

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