Plasma proteomics of acute tubular injury

Insa M. Schmidt (), Aditya L. Surapaneni, Runqi Zhao, Dhairya Upadhyay, Wan-Jin Yeo, Pascal Schlosser, Courtney Huynh, Anand Srivastava, Ragnar Palsson, Taesoo Kim, Isaac E. Stillman, Daria Barwinska, Jonathan Barasch, Michael T. Eadon, Tarek M. El-Achkar, Joel Henderson, Dennis G. Moledina, Sylvia E. Rosas, Sophie E. Claudel, Ashish Verma, Yumeng Wen, Maja Lindenmayer, Tobias B. Huber, Samir V. Parikh, John P. Shapiro, Brad H. Rovin, Ian B. Stanaway, Neha A. Sathe, Pavan K. Bhatraju, Josef Coresh, Eugene P. Rhee, Morgan E. Grams and Sushrut S. Waikar
Additional contact information
Insa M. Schmidt: Boston University Chobanian & Avedisian School of Medicine
Aditya L. Surapaneni: New York University Langone School of Medicine
Runqi Zhao: Boston University Chobanian & Avedisian School of Medicine
Dhairya Upadhyay: New York University Langone School of Medicine
Wan-Jin Yeo: New York University Langone School of Medicine
Pascal Schlosser: Johns Hopkins Bloomberg School of Public Health
Courtney Huynh: Boston University Chobanian & Avedisian School of Medicine
Anand Srivastava: University of Illinois Chicago
Ragnar Palsson: Massachusetts General Hospital
Taesoo Kim: Massachusetts General Hospital
Isaac E. Stillman: Icahn School of Medicine at Mount Sinai
Daria Barwinska: Indiana University School of Medicine
Jonathan Barasch: Columbia University Irving Medical Center
Michael T. Eadon: Indiana University School of Medicine
Tarek M. El-Achkar: Indiana University School of Medicine
Joel Henderson: Boston University Chobanian & Avedisian School of Medicine
Dennis G. Moledina: Yale School of Medicine
Sylvia E. Rosas: Harvard Medical School
Sophie E. Claudel: Boston University Chobanian & Avedisian School of Medicine
Ashish Verma: Boston University Chobanian & Avedisian School of Medicine
Yumeng Wen: Johns Hopkins University School of Medicine
Maja Lindenmayer: University Medical Center Hamburg-Eppendorf
Tobias B. Huber: University Medical Center Hamburg-Eppendorf
Samir V. Parikh: The Ohio State University Wexner Medical Center
John P. Shapiro: The Ohio State University Wexner Medical Center
Brad H. Rovin: The Ohio State University Wexner Medical Center
Ian B. Stanaway: University of Washington School of Medicine
Neha A. Sathe: University of Washington School of Medicine
Pavan K. Bhatraju: University of Washington School of Medicine
Josef Coresh: New York University Langone School of Medicine
Eugene P. Rhee: Massachusetts General Hospital
Morgan E. Grams: New York University Langone School of Medicine
Sushrut S. Waikar: Boston University Chobanian & Avedisian School of Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract The kidney tubules constitute two-thirds of the cells of the kidney and account for the majority of the organ’s metabolic energy expenditure. Acute tubular injury (ATI) is observed across various types of kidney diseases and may significantly contribute to progression to kidney failure. Non-invasive biomarkers of ATI may allow for early detection and drug development. Using the SomaScan proteomics platform on 434 patients with biopsy-confirmed kidney disease, we here identify plasma biomarkers associated with ATI severity. We employ regional transcriptomics and proteomics, single-cell RNA sequencing, and pathway analysis to explore biomarker protein and gene expression and enriched biological pathways. Additionally, we examine ATI biomarker associations with acute kidney injury (AKI) in the Kidney Precision Medicine Project (KPMP) (n = 44), the Atherosclerosis Risk in Communities (ARIC) study (n = 4610), and the COVID-19 Host Response and Clinical Outcomes (CHROME) study (n = 268). Our findings indicate 156 plasma proteins significantly linked to ATI with osteopontin, macrophage mannose receptor 1, and tenascin C showing the strongest associations. Pathway analysis highlight immune regulation and organelle stress responses in ATI pathogenesis.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-51304-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51304-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-51304-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().