Modelling variability and heterogeneity of EMT scenarios highlights nuclear positioning and protrusions as main drivers of extrusion

Steffen Plunder, Cathy Danesin, Bruno Glise, Marina A. Ferreira, Sara Merino-Aceituno () and Eric Theveneau ()
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Steffen Plunder: UPS
Cathy Danesin: UPS
Bruno Glise: UPS
Marina A. Ferreira: University of Coimbra
Sara Merino-Aceituno: University of Vienna
Eric Theveneau: UPS

Nature Communications, 2024, vol. 15, issue 1, 1-19

Abstract: Abstract Epithelial-Mesenchymal Transition (EMT) is a key process in physiological and pathological settings. EMT is often presented as a linear sequence with (i) disassembly of cell-cell junctions, (ii) loss of epithelial polarity and (iii) reorganization of the cytoskeleton leading to basal extrusion from the epithelium. Once out, cells can adopt a migratory phenotype with a front-rear polarity. While this sequence can occur, in vivo observations have challenged it. It is now accepted that multiple EMT scenarios coexist in heterogeneous cell populations. However, the relative importance of each step as well as that of variability and heterogeneity on the efficiency of cell extrusion has not been assessed. Here we used computational modelling to simulate multiple EMT-like scenarios and confronted these data to the EMT of neural crest cells. Overall, our data point to a key role of nuclear positioning and protrusive activity to generate timely basal extrusion.

Date: 2024
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DOI: 10.1038/s41467-024-51372-z

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