Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice

Paula Gómez-Sotres, Urszula Skupio, Tommaso Dalla Tor, Francisca Julio-Kalajzic, Astrid Cannich, Doriane Gisquet, Itziar Bonilla-Del Rio, Filippo Drago, Nagore Puente, Pedro Grandes, Luigi Bellocchio, Arnau Busquets-Garcia, Jaideep S. Bains () and Giovanni Marsicano ()
Additional contact information
Paula Gómez-Sotres: U1215 Neurocentre Magendie
Urszula Skupio: U1215 Neurocentre Magendie
Tommaso Dalla Tor: U1215 Neurocentre Magendie
Francisca Julio-Kalajzic: U1215 Neurocentre Magendie
Astrid Cannich: U1215 Neurocentre Magendie
Doriane Gisquet: U1215 Neurocentre Magendie
Itziar Bonilla-Del Rio: University of the Basque Country UPV/EHU
Filippo Drago: University of Catania
Nagore Puente: University of the Basque Country UPV/EHU
Pedro Grandes: University of the Basque Country UPV/EHU
Luigi Bellocchio: U1215 Neurocentre Magendie
Arnau Busquets-Garcia: PRBB
Jaideep S. Bains: University Health Network
Giovanni Marsicano: U1215 Neurocentre Magendie

Nature Communications, 2024, vol. 15, issue 1, 1-17

Abstract: Abstract Emotions and behavior can be affected by social chemosignals from conspecifics. For instance, olfactory signals from stressed individuals induce stress-like physiological and synaptic changes in naïve partners. Direct stress also alters cognition, but the impact of socially transmitted stress on memory processes is currently unknown. Here we show that exposure to chemosignals produced by stressed individuals is sufficient to impair memory retrieval in unstressed male mice. This requires astrocyte control of information in the olfactory bulb mediated by mitochondria-associated CB1 receptors (mtCB1). Targeted genetic manipulations, in vivo Ca2+ imaging and behavioral analyses reveal that mtCB1-dependent control of mitochondrial Ca2+ dynamics is necessary to process olfactory information from stressed partners and to define their cognitive consequences. Thus, olfactory bulb astrocytes provide a link between social odors and their behavioral meaning.

Date: 2024
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DOI: 10.1038/s41467-024-51416-4

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