The proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis

Wentao Zhao (), Cong Ouyang, Liang Zhang, Jinyang Wang, Jiaojiao Zhang, Yan Zhang, Chen Huang, Qiao Xiao, Bin Jiang, Furong Lin, Cixiong Zhang, Mingxia Zhu, Changchuan Xie, Xi Huang, Bingchang Zhang, Wenpeng Zhao, Jiawei He, Sifang Chen, Xiyao Liu, Donghai Lin, Qinxi Li () and Zhanxiang Wang ()
Additional contact information
Wentao Zhao: Xiamen University
Cong Ouyang: Xiamen University
Liang Zhang: Xiamen University
Jinyang Wang: Xiamen University
Jiaojiao Zhang: Xiamen University
Yan Zhang: Xiamen University
Chen Huang: Xiamen University
Qiao Xiao: Xiamen University
Bin Jiang: Xiamen University
Furong Lin: Xiamen University
Cixiong Zhang: Xiamen University
Mingxia Zhu: Xiamen University
Changchuan Xie: Xiamen University
Xi Huang: Xiamen University
Bingchang Zhang: Xiamen University
Wenpeng Zhao: Xiamen University
Jiawei He: Xiamen University
Sifang Chen: Xiamen University
Xiyao Liu: Xiamen University
Donghai Lin: Xiamen University
Qinxi Li: Xiamen University
Zhanxiang Wang: Xiamen University

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Increased fatty acid synthesis benefits glioblastoma malignancy. However, the coordinated regulation of cytosolic acetyl-CoA production, the exclusive substrate for fatty acid synthesis, remains unclear. Here, we show that proto-oncogene tyrosine kinase c-SRC is activated in glioblastoma and remodels cytosolic acetyl-CoA production for fatty acid synthesis. Firstly, acetate is an important substrate for fatty acid synthesis in glioblastoma. c-SRC phosphorylates acetyl-CoA synthetase ACSS2 at Tyr530 and Tyr562 to stimulate the conversion of acetate to acetyl-CoA in cytosol. Secondly, c-SRC inhibits citrate-derived acetyl-CoA synthesis by phosphorylating ATP-citrate lyase ACLY at Tyr682. ACLY phosphorylation shunts citrate to IDH1-catalyzed NADPH production to provide reducing equivalent for fatty acid synthesis. The c-SRC-unresponsive double-mutation of ACSS2 and ACLY significantly reduces fatty acid synthesis and hampers glioblastoma progression. In conclusion, this remodeling fulfills the dual needs of glioblastoma cells for both acetyl-CoA and NADPH in fatty acid synthesis and provides evidence for glioma treatment by c-SRC inhibition.

Date: 2024
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DOI: 10.1038/s41467-024-51444-0

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