Galectins induced from hemocytes bridge phosphatidylserine and N-glycosylated Drpr/CED-1 receptor during dendrite pruning

Hsin-Ho Sung, Hsun Li, Yi-Chun Huang, Chun-Lu Ai, Ming-Yen Hsieh, Hau-Ming Jan, Yu-Ju Peng, Hsien-Ya Lin, Chih-Hsuan Yeh, Shu-Yu Lin, Chun-Yen Yeh, Ying-Ju Cheng, Kay-Hooi Khoo, Chun-Hung Lin and Cheng-Ting Chien ()
Additional contact information
Hsin-Ho Sung: Academia Sinica
Hsun Li: Academia Sinica
Yi-Chun Huang: Academia Sinica
Chun-Lu Ai: Academia Sinica
Ming-Yen Hsieh: Academia Sinica
Hau-Ming Jan: Academia Sinica
Yu-Ju Peng: Academia Sinica
Hsien-Ya Lin: Academia Sinica
Chih-Hsuan Yeh: Academia Sinica
Shu-Yu Lin: Academia Sinica
Chun-Yen Yeh: Academia Sinica
Ying-Ju Cheng: Academia Sinica
Kay-Hooi Khoo: Academia Sinica
Chun-Hung Lin: Academia Sinica
Cheng-Ting Chien: Academia Sinica

Nature Communications, 2024, vol. 15, issue 1, 1-19

Abstract: Abstract During neuronal pruning, phagocytes engulf shed cellular debris to avoid inflammation and maintain tissue homeostasis. How phagocytic receptors recognize degenerating neurites had been unclear. Here, we identify two glucosyltransferases Alg8 and Alg10 of the N-glycosylation pathway required for dendrite fragmentation and clearance through genetic screen. The scavenger receptor Draper (Drpr) is N-glycosylated with complex- or hybrid-type N-glycans that interact specifically with galectins. We also identify the galectins Crouching tiger (Ctg) and Hidden dragon (Hdg) that interact with N-glycosylated Drpr and function in dendrite pruning via the Drpr pathway. Ctg and Hdg are required in hemocytes for expression and function, and are induced during dendrite injury to localize to injured dendrites through specific interaction with exposed phosphatidylserine (PS) on the surface membrane of injured dendrites. Thus, the galectins Ctg and Hdg bridge the interaction between PS and N-glycosylated Drpr, leading to the activation of phagocytosis.

Date: 2024
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DOI: 10.1038/s41467-024-51581-6

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