Sleep-like cortical dynamics during wakefulness and their network effects following brain injury

Marcello Massimini (), Maurizio Corbetta, Maria V. Sanchez-Vives, Thomas Andrillon, Gustavo Deco, Mario Rosanova and Simone Sarasso
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Marcello Massimini: University of Milan
Maurizio Corbetta: University of Padova
Maria V. Sanchez-Vives: Institut d’Investigacions Biomèdiques August Pi i Sunyer
Thomas Andrillon: CNRS
Gustavo Deco: Institució Catalana de la Recerca i Estudis Avançats (ICREA)
Mario Rosanova: University of Milan
Simone Sarasso: University of Milan

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract By connecting old and recent notions, different spatial scales, and research domains, we introduce a novel framework on the consequences of brain injury focusing on a key role of slow waves. We argue that the long-standing finding of EEG slow waves after brain injury reflects the intrusion of sleep-like cortical dynamics during wakefulness; we illustrate how these dynamics are generated and how they can lead to functional network disruption and behavioral impairment. Finally, we outline a scenario whereby post-injury slow waves can be modulated to reawaken parts of the brain that have fallen asleep to optimize rehabilitation strategies and promote recovery.

Date: 2024
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DOI: 10.1038/s41467-024-51586-1

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