Translation in Bacillus subtilis is spatially and temporally coordinated during sporulation

Olga Iwańska, Przemysław Latoch, Natalia Kopik, Mariia Kovalenko, Małgorzata Lichocka, Remigiusz Serwa and Agata L. Starosta ()
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Olga Iwańska: Pawinskiego 5a
Przemysław Latoch: Pawinskiego 5a
Natalia Kopik: Marii Curie-Skłodowskiej 5
Mariia Kovalenko: Pawinskiego 5a
Małgorzata Lichocka: Pawinskiego 5a
Remigiusz Serwa: M. Flisa 6
Agata L. Starosta: Pawinskiego 5a

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract The transcriptional control of sporulation in Bacillus subtilis is reasonably well understood, but its translational control is underexplored. Here, we use RNA-seq, ribosome profiling and fluorescence microscopy to study the translational dynamics of B. subtilis sporulation. We identify two events of translation silencing and describe spatiotemporal changes in subcellular localization of ribosomes during sporulation. We investigate the potential regulatory role of ribosomes during sporulation using a strain lacking zinc-independent paralogs of three zinc-dependent ribosomal proteins (L31, L33 and S14). The mutant strain exhibits delayed sporulation, reduced germination efficiency, dysregulated translation of metabolic and sporulation-related genes, and disruptions in translation silencing, particularly in late sporulation.

Date: 2024
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DOI: 10.1038/s41467-024-51654-6

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