Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children

Ambalavanan, Amirthagowri; Chang, Le; Choi, Jihoon; Zhang, Yang; Stickley, Sara A.; Fang, Zhi Y.; Miliku, Kozeta; Robertson, Bianca; Yonemitsu, Chloe; Turvey, Stuart E.; Mandhane, Piushkumar J.; Simons, Elinor; Moraes, Theo J.; Anand, Sonia S.; Paré, Guillaume; Williams, Janet E.; Murdoch, Brenda M.; Otoo, Gloria E.; Mbugua, Samwel; Kamau-Mbuthia, Elizabeth W.; Kamundia, Egidioh W.; Gindola, Debela K.; Rodriguez, Juan M.; Pareja, Rossina G.; Sellen, Daniel W.; Moore, Sophie E.; Prentice, Andrew M.; Foster, James A.; Kvist, Linda J.; Neibergs, Holly L.; McGuire, Mark A.; McGuire, Michelle K.; Meehan, Courtney L.; Sears, Malcolm R.; Subbarao, Padmaja; Azad, Meghan B.; Bode, Lars; Duan, Qingling

Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children

Amirthagowri Ambalavanan, Le Chang, Jihoon Choi, Yang Zhang, Sara A. Stickley, Zhi Y. Fang, Kozeta Miliku, Bianca Robertson, Chloe Yonemitsu, Stuart E. Turvey, Piushkumar J. Mandhane, Elinor Simons, Theo J. Moraes, Sonia S. Anand, Guillaume Paré, Janet E. Williams, Brenda M. Murdoch, Gloria E. Otoo, Samwel Mbugua, Elizabeth W. Kamau-Mbuthia, Egidioh W. Kamundia, Debela K. Gindola, Juan M. Rodriguez, Rossina G. Pareja, Daniel W. Sellen, Sophie E. Moore, Andrew M. Prentice, James A. Foster, Linda J. Kvist, Holly L. Neibergs, Mark A. McGuire, Michelle K. McGuire, Courtney L. Meehan, Malcolm R. Sears, Padmaja Subbarao, Meghan B. Azad (), Lars Bode () and Qingling Duan ()
Additional contact information
Amirthagowri Ambalavanan: Queen’s University
Le Chang: Queen’s University
Jihoon Choi: Queen’s University
Yang Zhang: Queen’s University
Sara A. Stickley: Queen’s University
Zhi Y. Fang: Queen’s University
Kozeta Miliku: McMaster University
Bianca Robertson: University of California San Diego
Chloe Yonemitsu: University of California San Diego
Stuart E. Turvey: University of British Columbia
Piushkumar J. Mandhane: University of Alberta
Elinor Simons: University of Manitoba
Theo J. Moraes: Hospital for Sick Children and University of Toronto
Sonia S. Anand: McMaster University
Guillaume Paré: McMaster University
Janet E. Williams: University of Idaho
Brenda M. Murdoch: University of Idaho
Gloria E. Otoo: University of Ghana
Samwel Mbugua: Egerton University
Elizabeth W. Kamau-Mbuthia: Egerton University
Egidioh W. Kamundia: Egerton University
Debela K. Gindola: Hawassa University
Juan M. Rodriguez: Complutense University of Madrid
Rossina G. Pareja: Nutrition Research Institute
Daniel W. Sellen: University of Toronto
Sophie E. Moore: King’s College London
Andrew M. Prentice: The Gambia at the London School of Hygiene & Tropical Medicine
James A. Foster: University of Idaho
Linda J. Kvist: Lund University
Holly L. Neibergs: Washington State University
Mark A. McGuire: University of Idaho
Michelle K. McGuire: University of Idaho
Courtney L. Meehan: Washington State University
Malcolm R. Sears: McMaster University
Padmaja Subbarao: McMaster University
Meghan B. Azad: University of Manitoba
Lars Bode: University of California San Diego
Qingling Duan: Queen’s University

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract Breastfeeding provides many health benefits, but its impact on respiratory health remains unclear. This study addresses the complex and dynamic nature of the mother-milk-infant triad by investigating maternal genomic factors regulating human milk oligosaccharides (HMOs), and their associations with respiratory health among human milk-fed infants. Nineteen HMOs are quantified from 980 mothers of the CHILD Cohort Study. Genome-wide association studies identify HMO-associated loci on chromosome 19p13.3 and 19q13.33 (lowest P = 2.4e–118), spanning several fucosyltransferase (FUT) genes. We identify novel associations on chromosome 3q27.3 for 6′-sialyllactose (P = 2.2e–9) in the sialyltransferase (ST6GAL1) gene. These, plus additional associations on chromosomes 7q21.32, 7q31.32 and 13q33.3, are replicated in the independent INSPIRE Cohort. Moreover, gene-environment interaction analyses suggest that fucosylated HMOs may modulate overall risk of recurrent wheeze among preschoolers with variable genetic risk scores (P

Date: 2024
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DOI: 10.1038/s41467-024-51743-6

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