Genome-wide DNA methylation profiling in blood reveals epigenetic signature of incident acute coronary syndrome

Pinpin Long, Jiahui Si, Ziwei Zhu, Yi Jiang, Yufei Wang, Qin Jiang, Wending Li, Xuedan Xu, Yutong You, Minghan Qu, Huihui Wang, Tingting Mo, Kang Liu, Jing Jiang, Qiuhong Wang, Canqing Yu, Yu Guo, Iona Y. Millwood, Robin G. Walters, Ximiao He, Yu Yuan, Hao Wang, Xiaomin Zhang, Meian He, Huan Guo, Zhengming Chen, Liming Li, Jun Lv (), Chaolong Wang () and Tangchun Wu ()
Additional contact information
Pinpin Long: Huazhong University of Science and Technology
Jiahui Si: Peking University
Ziwei Zhu: Huazhong University of Science and Technology
Yi Jiang: Huazhong University of Science and Technology
Yufei Wang: Huazhong University of Science and Technology
Qin Jiang: Huazhong University of Science and Technology
Wending Li: Huazhong University of Science and Technology
Xuedan Xu: Huazhong University of Science and Technology
Yutong You: Huazhong University of Science and Technology
Minghan Qu: Huazhong University of Science and Technology
Huihui Wang: Huazhong University of Science and Technology
Tingting Mo: Huazhong University of Science and Technology
Kang Liu: Huazhong University of Science and Technology
Jing Jiang: Huazhong University of Science and Technology
Qiuhong Wang: Huazhong University of Science and Technology
Canqing Yu: Peking University Health Science Center
Yu Guo: Fuwai Hospital, Chinese Academy of Medical Sciences
Iona Y. Millwood: University of Oxford
Robin G. Walters: University of Oxford
Ximiao He: Huazhong University of Science and Technology
Yu Yuan: Huazhong University of Science and Technology
Hao Wang: Huazhong University of Science and Technology
Xiaomin Zhang: Huazhong University of Science and Technology
Meian He: Huazhong University of Science and Technology
Huan Guo: Huazhong University of Science and Technology
Zhengming Chen: University of Oxford
Liming Li: Peking University Health Science Center
Jun Lv: Peking University Health Science Center
Chaolong Wang: Huazhong University of Science and Technology
Tangchun Wu: Huazhong University of Science and Technology

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract DNA methylation (DNAm) has been implicated in acute coronary syndrome (ACS), but the causality remains unclear in cross-sectional studies. Here, we conduct a prospective epigenome-wide association study of incident ACS in two Chinese cohorts (discovery: 751 nested case-control pairs; replication: 476 nested case-control pairs). We identified and validated 26 differentially methylated positions (DMPs, false discovery rate [FDR]

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-51751-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51751-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-51751-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().