Unveiling the solution structure of a DNA duplex with continuous silver-modified Watson-Crick base pairs
Uroš Javornik,
Antonio Pérez-Romero,
Carmen López-Chamorro,
Rachelle M. Smith,
José A. Dobado,
Oscar Palacios,
Mrinal K. Bera,
May Nyman (),
Janez Plavec () and
Miguel A. Galindo ()
Additional contact information
Uroš Javornik: National Institute of Chemistry
Antonio Pérez-Romero: Universidad de Granada
Carmen López-Chamorro: Universidad de Granada
Rachelle M. Smith: Oregon State University
José A. Dobado: Universidad de Granada
Oscar Palacios: Universitat Autònoma de Barcelona
Mrinal K. Bera: University of Chicago
May Nyman: Oregon State University
Janez Plavec: National Institute of Chemistry
Miguel A. Galindo: Universidad de Granada
Nature Communications, 2024, vol. 15, issue 1, 1-11
Abstract:
Abstract The challenge of transforming organized DNA structures into their metallized counterparts persists in the scientific field. In this context, utilizing DNA molecules modified with 7-deazapurine, provides a transformative solution. In this study, we present the solution structure of a DNA duplex that can be transformed into its metallized equivalent while retaining the natural base pairing arrangement through the creation of silver-modified Watson-Crick base pairs. Unlike previously documented X-ray structures, our research demonstrates the feasibility of preserving the intrinsic DNA self-assembly while incorporating AgI into the double helix, illustrating that the binding of silver does not disrupt the canonical base-pairing organization. Moreover, in our case, the uninterrupted AgI chain deviates from forming conventional straight linear chains; instead, it adheres to a helical arrangement dictated by the underlying DNA structure. This research challenges conventional assumptions and opens the door to precisely design structures based on the organization of highly stable Ag-DNA assemblies.
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51876-8
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DOI: 10.1038/s41467-024-51876-8
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