Unveiling the solution structure of a DNA duplex with continuous silver-modified Watson-Crick base pairs

Uroš Javornik, Antonio Pérez-Romero, Carmen López-Chamorro, Rachelle M. Smith, José A. Dobado, Oscar Palacios, Mrinal K. Bera, May Nyman (), Janez Plavec () and Miguel A. Galindo ()
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Uroš Javornik: National Institute of Chemistry
Antonio Pérez-Romero: Universidad de Granada
Carmen López-Chamorro: Universidad de Granada
Rachelle M. Smith: Oregon State University
José A. Dobado: Universidad de Granada
Oscar Palacios: Universitat Autònoma de Barcelona
Mrinal K. Bera: University of Chicago
May Nyman: Oregon State University
Janez Plavec: National Institute of Chemistry
Miguel A. Galindo: Universidad de Granada

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract The challenge of transforming organized DNA structures into their metallized counterparts persists in the scientific field. In this context, utilizing DNA molecules modified with 7-deazapurine, provides a transformative solution. In this study, we present the solution structure of a DNA duplex that can be transformed into its metallized equivalent while retaining the natural base pairing arrangement through the creation of silver-modified Watson-Crick base pairs. Unlike previously documented X-ray structures, our research demonstrates the feasibility of preserving the intrinsic DNA self-assembly while incorporating AgI into the double helix, illustrating that the binding of silver does not disrupt the canonical base-pairing organization. Moreover, in our case, the uninterrupted AgI chain deviates from forming conventional straight linear chains; instead, it adheres to a helical arrangement dictated by the underlying DNA structure. This research challenges conventional assumptions and opens the door to precisely design structures based on the organization of highly stable Ag-DNA assemblies.

Date: 2024
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DOI: 10.1038/s41467-024-51876-8

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