Influence of mRNA Covid-19 vaccine dosing interval on the risk of myocarditis

Stéphane Le Vu (), Marion Bertrand, Laura Semenzato, Marie-Joelle Jabagi, Jérémie Botton, Jérôme Drouin, Alain Weill, Rosemary Dray-Spira and Mahmoud Zureik
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Stéphane Le Vu: French National Health Insurance - CNAM)
Marion Bertrand: French National Health Insurance - CNAM)
Laura Semenzato: French National Health Insurance - CNAM)
Marie-Joelle Jabagi: French National Health Insurance - CNAM)
Jérémie Botton: French National Health Insurance - CNAM)
Jérôme Drouin: French National Health Insurance - CNAM)
Alain Weill: French National Health Insurance - CNAM)
Rosemary Dray-Spira: French National Health Insurance - CNAM)
Mahmoud Zureik: French National Health Insurance - CNAM)

Nature Communications, 2024, vol. 15, issue 1, 1-6

Abstract: Abstract Myocarditis is the most salient serious adverse event following messenger RNA-based Covid-19 vaccines. The highest risk is observed after the second dose compared to the first, whereas the level of risk associated with more distant booster doses seems to lie in between. We aimed to assess the relation between dosing interval and the risk of myocarditis, for both the two-dose primary series and the third dose (first booster). This matched case-control study included 7911 cases of myocarditis aged 12 or more in a period where approximately 130 million vaccine doses were administered. Here we show that longer intervals between each consecutive dose, including booster, may decrease the occurrence of vaccine-associated myocarditis by up to a factor of 4, especially under age 50. These results suggest that a minimum 6-month interval might be required when scheduling additional booster vaccination.

Date: 2024
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DOI: 10.1038/s41467-024-52038-6

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