Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards

Federico Torta, Nils Hoffmann, Bo Burla, Irina Alecu, Makoto Arita, Takeshi Bamba, Steffany A. L. Bennett, Justine Bertrand-Michel, Britta Brügger, Mónica P. Cala, Dolores Camacho-Muñoz, Antonio Checa, Michael Chen, Michaela Chocholoušková, Michelle Cinel, Emeline Chu- Van, Benoit Colsch, Cristina Coman, Lisa Connell, Bebiana C. Sousa, Alex M. Dickens, Maria Fedorova, Finnur Freyr Eiríksson, Hector Gallart-Ayala, Mohan Ghorasaini, Martin Giera, Xue Li Guan, Mark Haid, Thomas Hankemeier, Amy Harms, Marcus Höring, Michal Holčapek, Thorsten Hornemann, Chunxiu Hu, Andreas J. Hülsmeier, Kevin Huynh, Christina M. Jones, Julijana Ivanisevic, Yoshihiro Izumi, Harald C. Köfeler, Sin Man Lam, Mike Lange, Jong Cheol Lee, Gerhard Liebisch, Katrice Lippa, Andrea F. Lopez-Clavijo, Malena Manzi, Manuela R. Martinefski, Raviswamy G. H. Math, Satyajit Mayor, Peter J. Meikle, María Eugenia Monge, Myeong Hee Moon, Sneha Muralidharan, Anna Nicolaou, Thao Nguyen-Tran, Valerie B. O’Donnell, Matej Orešič, Arvind Ramanathan, Fabien Riols, Daisuke Saigusa, Tracey B. Schock, Heidi Schwartz-Zimmermann, Guanghou Shui, Madhulika Singh, Masatomo Takahashi, Margrét Thorsteinsdóttir, Noriyuki Tomiyasu, Anthony Tournadre, Hiroshi Tsugawa, Victoria J. Tyrrell, Grace Gugten, Michael O. Wakelam, Craig E. Wheelock, Denise Wolrab, Guowang Xu, Tianrun Xu, John A. Bowden, Kim Ekroos (), Robert Ahrends () and Markus R. Wenk ()
Additional contact information
Federico Torta: National University of Singapore
Nils Hoffmann: Forschungszentrum Jülich GmbH
Bo Burla: National University of Singapore
Irina Alecu: University of Ottawa
Makoto Arita: RIKEN Center for Integrative Medical Sciences
Takeshi Bamba: Kyushu University
Steffany A. L. Bennett: University of Ottawa
Justine Bertrand-Michel: MetaboHUBMetaToul Facility
Britta Brügger: Heidelberg University Biochemistry Center (BZH)
Mónica P. Cala: Universidad de los Andes
Dolores Camacho-Muñoz: Manchester Academic Health Science Centre
Antonio Checa: Karolinska Institutet
Michael Chen: University of British Columbia
Michaela Chocholoušková: University of Pardubice
Michelle Cinel: Baker Heart and Diabetes Institute
Emeline Chu- Van: MetaboHUB
Benoit Colsch: MetaboHUB
Cristina Coman: University of Vienna
Lisa Connell: Avanti Polar Lipids
Bebiana C. Sousa: Babraham Research Campus
Alex M. Dickens: University of Turku and Åbo Akademi University
Maria Fedorova: University of Leipzig
Finnur Freyr Eiríksson: University of Iceland
Hector Gallart-Ayala: University of Lausanne
Mohan Ghorasaini: Leiden University Medical Center
Martin Giera: Leiden University Medical Center
Xue Li Guan: Nanyang Technological University
Mark Haid: German Research Center for Environmental Health
Thomas Hankemeier: Leiden University
Amy Harms: Leiden University
Marcus Höring: Institute of Clinical Chemistry and Laboratory Medicine
Michal Holčapek: University of Pardubice
Thorsten Hornemann: University Zurich
Chunxiu Hu: Chinese Academy of Sciences
Andreas J. Hülsmeier: University Zurich
Kevin Huynh: Baker Heart and Diabetes Institute
Christina M. Jones: National Institute of Standards and Technology
Julijana Ivanisevic: University of Lausanne
Yoshihiro Izumi: Kyushu University
Harald C. Köfeler: Medical University of Graz
Sin Man Lam: LipidALL Technologies
Mike Lange: University of Leipzig
Jong Cheol Lee: Yonsei University
Gerhard Liebisch: Institute of Clinical Chemistry and Laboratory Medicine
Katrice Lippa: National Institute of Standards and Technology
Andrea F. Lopez-Clavijo: Babraham Research Campus
Malena Manzi: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
Manuela R. Martinefski: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
Raviswamy G. H. Math: Tata Institute of Fundamental Research
Satyajit Mayor: Tata Institute of Fundamental Research
Peter J. Meikle: Baker Heart and Diabetes Institute
María Eugenia Monge: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
Myeong Hee Moon: Yonsei University
Sneha Muralidharan: National University of Singapore
Anna Nicolaou: Manchester Academic Health Science Centre
Thao Nguyen-Tran: University of Ottawa
Valerie B. O’Donnell: Cardiff University
Matej Orešič: University of Turku and Åbo Akademi University
Arvind Ramanathan: Institute for Stem Cell Science and Regenerative Medicine
Fabien Riols: German Research Center for Environmental Health
Daisuke Saigusa: Teikyo University
Tracey B. Schock: National Institute of Standards and Technology
Heidi Schwartz-Zimmermann: Vienna (BOKU)
Guanghou Shui: Chinese Academy of Sciences
Madhulika Singh: Leiden University
Masatomo Takahashi: Kyushu University
Margrét Thorsteinsdóttir: University of Iceland
Noriyuki Tomiyasu: Kyushu University
Anthony Tournadre: MetaboHUBMetaToul Facility
Hiroshi Tsugawa: RIKEN Center for Integrative Medical Sciences
Victoria J. Tyrrell: Cardiff University
Grace Gugten: Department of Pathology and Laboratory Medicine
Michael O. Wakelam: Babraham Research Campus
Craig E. Wheelock: Karolinska Institutet
Denise Wolrab: University of Pardubice
Guowang Xu: Chinese Academy of Sciences
Tianrun Xu: Chinese Academy of Sciences
John A. Bowden: University of Florida
Kim Ekroos: Lipidomics Consulting Ltd.
Robert Ahrends: University of Vienna
Markus R. Wenk: National University of Singapore

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract In this community effort, we compare measurements between 34 laboratories from 19 countries, utilizing mixtures of labelled authentic synthetic standards, to quantify by mass spectrometry four clinically used ceramide species in the NIST (National Institute of Standards and Technology) human blood plasma Standard Reference Material (SRM) 1950, as well as a set of candidate plasma reference materials (RM 8231). Participants either utilized a provided validated method and/or their method of choice. Mean concentration values, and intra- and inter-laboratory coefficients of variation (CV) were calculated using single-point and multi-point calibrations, respectively. These results are the most precise (intra-laboratory CVs ≤ 4.2%) and concordant (inter-laboratory CVs

Date: 2024
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DOI: 10.1038/s41467-024-52087-x

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