Hybrid lipid-AuNP clusters as highly efficient SERS substrates for biomedical applications

Jacopo Cardellini, Caterina Dallari, Ilaria Santis, Lorenzo Riccio, Costanza Ceni, Amelia Morrone, Martino Calamai, Francesco Saverio Pavone, Caterina Credi, Costanza Montis and Debora Berti ()
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Jacopo Cardellini: University of Florence
Caterina Dallari: European Laboratory for Non-Linear Spectroscopy (LENS)
Ilaria Santis: University of Florence
Lorenzo Riccio: University of Florence
Costanza Ceni: University of Florence
Amelia Morrone: Meyer Children’s Hospital IRCCS
Martino Calamai: European Laboratory for Non-Linear Spectroscopy (LENS)
Francesco Saverio Pavone: European Laboratory for Non-Linear Spectroscopy (LENS)
Caterina Credi: European Laboratory for Non-Linear Spectroscopy (LENS)
Costanza Montis: University of Florence
Debora Berti: University of Florence

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Although Surface Enhanced Raman Scattering (SERS) is widely applied for ultrasensitive diagnostics and imaging, its potential is largely limited by the difficult preparation of SERS tags, typically metallic nanoparticles (NPs) functionalized with Raman-active molecules (RRs), whose production often involves complex synthetic approaches, low colloidal stability and poor reproducibility. Here, we introduce LipoGold Tags, a simple platform where gold NPs (AuNPs) clusters form via self-assembly on lipid vesicle. RRs embedded in the lipid bilayer experience enhanced electromagnetic field, significantly increasing their Raman signals. We modulate RRs and lipid vesicle concentrations to achieve optimal SERS enhancement and we provide robust structural characterization. We further demonstrate the versatility of LipoGold Tags by functionalizing them with biomolecular probes, including antibodies. As proof of concept, we successfully detect intracellular GM1 alterations, distinguishing healthy donors from patients with infantile GM1 gangliosidosis, showcasing LipoGold Tags as advancement in SERS probes production.

Date: 2024
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DOI: 10.1038/s41467-024-52205-9

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