Integrated landscape of plasma metabolism and proteome of patients with post-traumatic deep vein thrombosis

Kun Zhang, Pengfei Wang, Wei Huang, Shi-Hao Tang, Hanzhong Xue, Hao Wu, Ying Zhang, Yu Rong, Shan-Shan Dong, Jia-Bin Chen, Yan Zou, Ding Tian, Na Yang, Yifan Liang, Chungui Liu, Dongyang Li, Kun Zhang (), Tie-Lin Yang () and Yan Guo ()
Additional contact information
Kun Zhang: Xi’an Jiaotong University
Pengfei Wang: Xi’an Jiaotong University
Wei Huang: Xi’an Jiaotong University
Shi-Hao Tang: Xi’an Jiaotong University
Hanzhong Xue: Xi’an Jiaotong University
Hao Wu: Xi’an Jiaotong University
Ying Zhang: Xi’an Jiaotong University
Yu Rong: Xi’an Jiaotong University
Shan-Shan Dong: Xi’an Jiaotong University
Jia-Bin Chen: Xi’an Jiaotong University
Yan Zou: Xi’an Jiaotong University
Ding Tian: Xi’an Jiaotong University
Na Yang: Xi’an Jiaotong University
Yifan Liang: Xi’an Jiaotong University
Chungui Liu: Xi’an Jiaotong University
Dongyang Li: Xi’an Jiaotong University
Kun Zhang: Xi’an Jiaotong University
Tie-Lin Yang: Xi’an Jiaotong University
Yan Guo: Xi’an Jiaotong University

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Deep vein thrombosis (DVT) is a leading cause of morbidity and mortality after trauma. Here, we integrate plasma metabolomics and proteomics to evaluate the metabolic alterations and their function in up to 680 individuals with and without DVT after trauma (pt-DVT). We identify 28 metabolites and 2 clinical parameter clusters associated with pt-DVT. Then, we develop a panel of 9 metabolites (hexadecanedioic acid, pyruvic acid, L-Carnitine, serotonin, PE(P-18:1(11Z)/18:2(9Z,12Z)), 3-Hydroxycapric acid, 5,6-DHET, 3-Methoxybenzenepropanoic acid and pentanenitrile) that can predict pt-DVT with high performance, which can be verified in an independent cohort. Furthermore, the integration analysis of metabolomics and proteomics data indicates that the upregulation of glycolysis/gluconeogenesis-TCA cycle may promote thrombosis by regulating ROS levels in red blood cells, suggesting that interfering with this process might be potential therapeutic strategies for pt-DVT. Together, our study comprehensively delineates the metabolic and hematological dysregulations for pt-DVT, and provides potential biomarkers for early detection.

Date: 2024
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DOI: 10.1038/s41467-024-52262-0

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