Lattice expansion in ruthenium nanozymes improves catalytic activity and electro-responsiveness for boosting cancer therapy

Songjing Zhong, Zeyu Zhang, Qinyu Zhao, Zhaoyang Yue, Cheng Xiong, Genglin Chen, Jie Wang and Linlin Li ()
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Songjing Zhong: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Zeyu Zhang: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Qinyu Zhao: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Zhaoyang Yue: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Cheng Xiong: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Genglin Chen: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Jie Wang: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences
Linlin Li: Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Nanozymes have been attracting widespread interest for the past decade, especially in the field of cancer therapy, due to their intrinsic catalytic activities, strong stability, and ease of synthesis. However, enhancing their catalytic activity in the tumor microenvironment (TME) remains a major challenge. Herein, we manipulate catalytic activities of Ru nanozymes via modulating lattice spacing in Ru nanocrystals supported on nitrogen-doped carbon support, to achieve improvement in multiple enzyme-like activities that can form cascade catalytic reactions to boost cancer cell killing. In addition, the lattice expansion in Ru nanocrystals improve the responsiveness of the nanozymes to self-powered electric field, achieving maximized cancer therapeutic outcome. Under the electrical stimulation provided by a human self-propelled triboelectric device, the Ru-based nanozyme (Ru1000) with a lattice expansion of 5.99% realizes optimal catalytic performance and cancer therapeutic outcome of breast cancer in female tumor-bearing mice. Through theoretical calculations, we uncover that the lattice expansion and electrical stimulation promote the catalytic reaction, simultaneously, by reducing the electron density and shifting the d-band center of Ru active sites. This work provides opportunities for improving the development of nanozymes.

Date: 2024
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DOI: 10.1038/s41467-024-52277-7

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